FISH for IGH/BCL2 Tissue

Test Mnemonic


CPT Codes

  • 88377 - QTY (2)


  • FISH for t(14;18)


  • LSI 14q32.33
  • LSI 18q21.33

Performing Laboratory

Cleveland Clinic Laboratories

Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2 slidesSlide (s), unstainedClean containerAmbientAmbient4 μm tissue sections on electrostatically charged slides containing representative tissue. Tissue must be formalin fixed. Samples must not be fixed in B5 or Prefer fixative.


Environmental Condition Description
AmbientBlocks and slides should be transported at ambient temperature.

Days Performed

5 days per week

Turnaround Time

3 - 5 days


Name Description
Fluorescent In-Situ Hybridization (FISH) 

Clinical Info

Interphase FISH analysis utilizing a dual color, dual fusion probe set specific to the IGH gene at 14q32.33 and the BCL2 gene at 18q21.33. This is useful in identifying the t(14;18) translocation present in follicular lymphoma and diffuse large B-cell lymphoma. If no cells are available for analysis, no analysis charges will be incurred.