FISH for IGH/MYC/CEP8 Tissue
Test Mnemonic
T814
CPT Codes
- 88377 - QTY (1)
Aliases
- FISH for t(8;14)
Includes
- LSI 8q24.1
- LSI 14q32.33
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 slides | Slide (s), unstained | Clean container | Ambient | 4 μm tissue sections on electrostatically charged slides. Tissue must be formalin fixed. Samples must not be fixed in Prefer or B5. |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Blocks and slides should be transported at ambient temperature. |
Days Performed
5 days per week
Turnaround Time
3 - 5 days
Methodology
| Name | Description |
|---|---|
| Fluorescent In-Situ Hybridization (FISH) |
Clinical Info
Interphase FISH analysis utilizing a three color, dual fusion probe set specific to the MYC gene at 8q24.1 and the IGH gene at 14q32.33, in conjunction with the centromere of chromosomes 8. The t(8;14) rearrangement may be seen in Burkitt lymphoma and double hit B-cell lymphomas. If no cells are available for analysis, no analysis charges will be incurred.