FISH for MALT 1 (18q21)
Test Mnemonic
MALT1
CPT Codes
- 88377 - QTY (1)
Aliases
- FISH for assessment of Extranodal Marginal Zone B
- Fluorescence In Situ Hybridization for MALT 1 (18q21)
Includes
- LSI 18q21.3
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 slides | Slide (s), unstained | Clean container | Ambient | One formalin-fixed, paraffin embedded block containing representative tissue OR unstained 4 μm tissue sections on electrostatically charged slides containing representative tumor. Tissue must be fixed in formalin NOT B5 or PREFER fixative |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Sample is formalin fixed and must not be fixed in Prefer or B5. |
Days Performed
5 days per week
Turnaround Time
3 - 5 days
Methodology
| Name | Description |
|---|---|
| Fluorescent In-Situ Hybridization (FISH) |
Clinical Info
Interphase FISH analysis utilizing a dual color, break-apart probes for the MALT1 gene at 18q21.3. Rearrangements of the MALT1 gene are observed in marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. The translocation partner gene cannot be identified in this assay. If no cells are available for analysis, no analysis charges will be incurred.