FISH for RET Cyto Block
- 88377 - QTY (1)
- LSI 10q11
Cleveland Clinic Laboratories
|Volume||Type||Container||Collect Temperature||Transport Temperature||Special Instructions|
|4 slides||cytologic preparation (slide)||Slides||Ambient||Ambient||Cytology cell blocks that have been formalin fixed OR 4 μm formalin fixed paraffin-embedded tissue sections on electrostatically charged slides containing representative tumor, including Pre-H&E. Samples must not be fixed in Prefer or B5.|
|Ambient||Cell block slides are acceptable|
5 days per week
5 - 7 days
|Fluorescent In-Situ Hybridization (FISH)|
Interphase FISH analysis utilizing a dual color, break-apart probe for the RET gene at 10q11.21. Rearrangements involving RET may be seen in individuals with late-stage, lung adenocarcinomas that are negative for EGFR and ALK rearrangements. The translocation partner gene cannot be identified in this assay. If no cells are available for analysis, no analysis charges will be incurred.
This assay has been validated for cell blocks prepared from cytology samples fixed in PreservCyt solution using the Cellient Automated Cell Block System (Hologic, Marlborough, MA). Blocks prepared with other fixatives and/or methods are not acceptable.