Fructosamine
Test Mnemonic
FRUCTO
CPT Codes
- 82985 - QTY (1)
LOINC ®
15069-8
Aliases
- Protein Bound Glucose
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL | Serum | SST (Gold) | Refrigerated |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL | Plasma | Green LiHep Nogel | Refrigerated | Separate plasma from cells within 2 hours of collection and transfer to standard aliquot tube. | |
| 0.5 mL | Plasma | EDTA (Lavender) | Refrigerated | Separate plasma from cells within 2 hours of collection and transfer to standard aliquot tube. | |
| 0.5 mL | Plasma | Lithium heparin PST (Lt. Green) | Refrigerated | ||
| 0.5 mL | Serum | Red Plain | Refrigerated | Allow specimen to clot completely at room temperature. Separate serum from cells within 2 hours of collection and transfer to standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.3 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 72 hours |
| Refrigerated | After separation from cells: 2 weeks |
| Frozen | After separation from cells: 2 months |
Days Performed
Mon - Fri
Turnaround Time
2 - 3 days
Methodology
| Name | Description |
|---|---|
| Colorimetric, Kinetic |
Reference Range
| Fructosamine | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | 205 - 285 | umol/L |
Special Info
Fructosamine is affected by the presence of reducing molecules in the blood, such as bilirubin and ascorbic acid (vitamin C). Patients are advised to abstain from ascorbic acid supplements 24 hours prior to sample collection. Hypoproteinemic related conditions may affect fructosamine concentrations. Stability of EDTA whole blood before separation of cells was validated at 72 hours for ambient storage and 7 days of refrigerated storage.
Clinical Info
Fructosamine is an useful alternative indicator of glycemic control in conditions in which HbA1c measurement is unreliable and for identifying impaired blood glucose control prior to noticeable changes in HbA1c. Fructosamine should not be used as a substitute for HbA1c except in specific patient populations (e.g. unreliable HbA1c due to interfering hemoglobin variants). Fructosamine concentrations may be affected by altered concentrations of protein in blood.
Clinical Limitation
High levels of ascorbic acid interfere with the fructosamine assay. Hemolyzed samples with hemolysis index >100mg/dL may be rejected. Icteric samples with icteric index >5mg/dL may be rejected.