GM1 Antibody Panel | Cleveland Clinic Laboratories

GM1 Antibody Panel Print

Test Mnemonic

GM1ABP

CPT Codes

83516 - QTY (2)

Includes

GM1 Antibody IgG
GM1 Antibody IgM

Performing Laboratory

ARUP

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
0.3 mL	Serum	SST (Gold)		Refrigerated	Separate serum from cells ASAP or within 2 hours of collection

Minimum Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
0.1 mL

Stability

Environmental Condition	Description
Ambient	Unacceptable
Refrigerated	After separation from cells: 2 weeks
Frozen	After separation from cells: 1 year

Days Performed

Mon, Wed, Fri

Turnaround Time

2 - 5 days

Methodology

Name	Description
Semi Quantitative Enzyme Linked Immunosorbent Assay

Reference Range

GM1 Antibody IgG
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	Negative: < or = 29	IV
	Years	99 Years	Normal	Equivocal: 30 - 50	IV
	Years	99 Years	Normal	Positive: 51 - 100	IV
	Years	99 Years	Normal	Strong Positive: > or = 101	IV
GM1 Antibody IgM
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	Negative: < or = 29	IV
	Years	99 Years	Normal	Equivocal: 30 - 50	IV
	Years	99 Years	Normal	Positive: 51 - 100	IV
	Years	99 Years	Normal	Strong Positive: > or = 101	IV

Special Info

Unacceptable conditions: heat inactivated, severely lipemic, contaminated or hemolyzed specimens.

Clinical Info

Elevated antibody levels to ganglioside-monosialic acid (GM1) are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies. These antibodies may also be found in patients with diverse connective tissue diseases as well as normal individuals. These tests by themselves are not diagnostic and should be used in conjunction with other clinical parameters to confirm disease.