Hypercoagulation Diagnostic Interpretive Panel | Cleveland Clinic Laboratories

Hypercoagulation Diagnostic Interpretive Panel Print

Test Mnemonic

HYPER

CPT Codes

86147 - QTY (3)
85610 - QTY (1)
85730 - QTY (1)
85384 - QTY (1)
85303 - QTY (1)
86140 - QTY (1)
81240 - QTY (1)
85390 - QTY (1)
85670 - QTY (1)
85520 - QTY (1)
85730 - QTY (1)
85240 - variable - QTY (1)
85307 - variable - QTY (1)
85300 - variable - QTY (1)
85306 - variable - QTY (1)
85730 - variable - QTY (1)
85598-variable - QTY (1)
85732 - variable - QTY (1)

Aliases

Hypercoagulation Panel
Hyper Panel

Includes

Prothrombin Time (PT)
APTT
Fibrinogen
Cardiolipin Antibodies
C-Reactive Protein
APTTSC
TT
ANTIXA
Protein C Functional
PTGEN
FVIIIC
Antithrombin Assay
PROT S Clot
STACLOT LA
APC

Performing Laboratory

Cleveland Clinic Laboratories

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
2 mL	Serum	SST (Gold)		Frozen	Indicate clearly which tube is plasma and which tube is serum. Submit Coagulation Consultation Patient History Form.
4 mL	Whole blood	EDTA (Lavender)		Refrigerated
6 mL	Plasma	Sodium citrate (Lt. Blue)	See note	Centrifuge, aliquot and freeze ASAP.	Collection tubes must be filled to total fill volume. Inadequately filled and clotted tubes will be rejected. Non-testing sites: Centrifuge samples; Aliquot plasma into separate tubes and label with Epic Beaker labels, DO NOT POUR SPECIMENS TOGETHER. Specimens should be frozen (-20C or colder).

Minimum Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
2 mL					Whole blood EDTA (Lavender)
1 mL					Serum
3 mL					Citrated plasma. NOTE: If only the minimum volume is received, some reflex testing may not be able to be performed.

Stability

Environmental Condition	Description
Ambient	Main campus: ACCEPTABLE for Whole Blood. (Must be delivered ambient to testing lab less than 4 hours post collection.) Non-Testing Sites: UNACCEPTABLE.
Frozen	For Non-Testing sites, Frozen Plasma is ACCEPTABLE. Centrifuge samples, then aliquot plasma into separate tubes and label with Epic Beaker labels. DO NOT COMBINE TUBES. Specimens should be frozen (-20° C or colder) and they are stable for 2 weeks. (6 months at -70° C)
Refrigerated	Unacceptable

Days Performed

Mon - Fri

Turnaround Time

3 - 5 days

Methodology

Name	Description
Refer to individual components

Reference Range

APTT Screen
Sex	Age From	Age To	Type	Range	Range Unit
	Days	1 Days	Normal	28.2-47.4	sec
	1 Months	3 Months	Normal	21.7-43.5	sec
	2 Days	5 Days	Normal	22.9-52.0	sec
	6 Days	30 Days	Normal	23.1-48.0	sec
	4 Months	11 Months	Normal	25.3-37.3	sec
	1 Years	5 Years	Normal	21.3-31.6	sec
	6 Years	10 Years	Normal	23.1-31.6	sec
	11 Years	16 Years	Normal	23.1-32.5	sec
	17 Years	99 Years	Normal	24.0-35.1	sec
Thrombin Time
Sex	Age From	Age To	Type	Range	Range Unit
	Days	1 Days	Normal	< 17.3	sec
	2 Days	5 Days	Normal	< 17.9	sec
	6 Days	30 Days	Normal	< 17.9	sec
	1 Months	3 Months	Normal	< 18.2	sec
	4 Months	11 Months	Normal	< 19.1	sec
	1 Years	999 Years	Normal	< 18.6	sec

Special Info

Patient Preparation: Discontinue coumadin therapy for 7 days, heparin therapy for 2 days and thrombolytic therapy for 7 days prior to test, if possible. 3.2% sodium citrate is the preferred anticoagulant recommended by CLSI. Per Pathologist review, the following tests may be ordered and billed: ATIII Antigen (85301); PTT Incubated Mixing Add On (85730, 85732 x2); Dilute Russell Viper Venom (85613); Platelet Neutralization (85597); Factor V Leiden (81241); Reptilase (85635); Fibrinogen Antigen (85385); D-Dimer (85379); Prot C Immunologic (85302); Factor 8 chromogenic (85240); Sample must be accompanied by the completed Clinical History Form for Hemostasis and Thrombosis Evaluation and a medication list.

Clinical Info

Use in the evaluation of congenital or acquired disorders associated with a hypercoagulable state.