Kappa/Lambda, Free, Serum




Test Mnemonic

KLFRS

CPT Codes

  • 83521 - QTY (2)

Aliases

  • Free Kappa/Lambda Light Chains

Includes

  • Kappa, Free
  • Lambda, Free
  • Kappa/Lambda Ratio

Performing Laboratory

Cleveland Clinic Laboratories


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumSST (Gold) Refrigerated 

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.5 mL     

Stability

Environmental Condition Description
Ambient24 hours
Refrigerated21 days
Frozen30 days

Days Performed

Mon - Fri

Turnaround Time

1 - 4 days

Methodology

Name Description
Turbidimetry (TURB) 

Reference Range

Kappa, Free, Serum
Sex Age From Age To Type Range Range Unit
       Normal3.30-19.40mg/L
Kappa/Lambda Ratio
Sex Age From Age To Type Range Range Unit
       0.26-1.65 
Lambda, Free, Serum
Sex Age From Age To Type Range Range Unit
       Normal5.7 - 26.3mg/L

Special Info

The Kappa Free Light Chain was performed using the Binding Site Optilite immunoturbidimetric method. Result obtained with different assay methods or kits cannot be used interchangeably. The Lambda Free Light Chain was performed using the Binding Site Optilite immunoturbidimetric method. Result obtained with different assay methods or kits cannot be used interchangeably.

Clinical Info

Elevated serum levels of monoclonal free light chains are associated with malignant plasma cell proliferation (eg. multiple myeloma), AL amyloidosis, and light chain deposition disease. Raised serum levels of polyclonal free light chains may be associated with autoimmune diseases or chronic infectious diseases.

Clinical Limitation

This assay has not been validated for the pediatric population.