Ketamine & Metabolite, Serum/Plasma
Test Mnemonic
KETMIN
CPT Codes
- 80357 - QTY (1)
- G0480 - QTY (1)
Aliases
- Ketalar
Includes
- Ketamine
- Norketamine
Performing Laboratory
National Med Serv Inc
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Serum | No additive (Red) | Refrigerated | Do not use SST tube. Promptly centrifuge and separate serum into a plastic screw capped vial. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Plasma | Sodium or Lithium heparin (Green) | Refrigerated | Do not use PST tube. Promptly centrifuge and separate plasma into a plastic screw capped vial. | |
| 3 mL | Plasma | EDTA (Lavender) | Refrigerated | Please collect two EDTA lavender top tubes. Promptly centrifuge and separate plasma into a plastic screw capped vial. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1.2 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 14 days |
| Frozen | 9 months |
| Refrigerated | 14 days |
Days Performed
Mon - Sun
Turnaround Time
6 - 7 days
Methodology
| Name | Description |
|---|---|
| Gas Chromatography Mass Spectrometry (GCMS) |
Reference Range
| Ketamine, Serum/Plasma | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Freetext | Reported levels during aneasthesia: 500-6500 ng/mL | ||||
| Norketamine, Serum/Plasma | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Freetext | The intravenous administration of 2 mg/kg of Ketamine followed by continuous infusion of 41 mcg/kg/minute produced an average steady-state plasma concentration of 2200 ng Ketamine/mL and an average peak Norketamine level of 1050 ng/mL which occurred near the end of the 3 hour infusion. |
Special Info
Polymer gel separation tubes (SST or PST) will be rejected. Reporting limit: 20 ng/mL for both Norketamine and Ketamine. This test is New York DOH approved.
Clinical Info
Ketamine is rapidly distributed into brain and other perfused tissues. The plasma half-life is two to three hours. Oral administration produces lower peak concentrations of ketamine. Drowsiness, perceptual distortions and intoxication may be dose related in a plasma concentration range of 50 - 200 ng/mL. Urinary excretion of unchanged drug is in the range of 1 - 10% and ketamine can be detected in urine for about three days. Concentration ranges for ketamine in urine have been reported as low as 10 ng/mL and as high as 25,000 ng/mL.