Liver Kidney Microsome IgG Autoabs




Test Mnemonic

LKM

CPT Codes

  • 86376 - QTY (1)

LOINC ®

9838-4

Aliases

  • Anti-LKM
  • Liver Kidney Microsomal Abs
  • Liver-Kidney Microsome Antibody, IgG
  • LKM-1 Abs

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumSST (Gold) RefrigeratedTransfer 1 mL serum to standard aliquot tube.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.15 mL     

Stability

Environmental Condition Description
RefrigeratedAfter separation from cells: 2 weeks
FrozenAfter separation from cells: 1 year (Avoid repeated freeze/thaw cycles)
AmbientAfter separation from cells: 48 hours

Days Performed

Mon - Sat

Turnaround Time

2 - 4 days

Methodology

Name Description
Semi-Quantitative Indirect Fluorescent Antibody 

Reference Range

Liver Kidney Microsome IgG Autoabs
Sex Age From Age To Type Range Range Unit
       Normal: < 1:20 

Special Info

Severely hemolyzed or lipemic specimens are unacceptable. This test is New York DOH approved.

Clinical Info

Differential evaluation of autoimmune liver disease of unknown etiology, especially autoimmune hepatitis (AIH) of childhood onset. Liver-Kidney Microsome IgG antibody (anti-LKM), as detected by indirect immunofluorescent antibody (IFA) techniques, may be observed in patients with autoimmune hepatitis type 2 (AIH-2), AIH-2 associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), viral hepatitis C or D, and some forms of drug-induced hepatitis. This IFA does not differentiate among the four types of LKM antibodies (LKM-1, LKM-2, LKM-3, and a fourth type that recognizes CYP1A2 and CYP2A6 antigens). Of these, anti-LKM-1 (cytochrome P450IID6) IgG antibodies are considered specific for AIH-2.