Liver Kidney Microsome IgG Autoabs
Test Mnemonic
LKM
CPT Codes
- 86376 - QTY (1)
LOINC ®
9838-4
Aliases
- Anti-LKM
- Liver Kidney Microsomal Abs
- Liver-Kidney Microsome Antibody, IgG
- LKM-1 Abs
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Refrigerated | Transfer 1 mL serum to standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.15 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | After separation from cells: 2 weeks |
| Frozen | After separation from cells: 1 year (Avoid repeated freeze/thaw cycles) |
| Ambient | After separation from cells: 48 hours |
Days Performed
Mon - Sat
Turnaround Time
2 - 4 days
Methodology
| Name | Description |
|---|---|
| Semi-Quantitative Indirect Fluorescent Antibody |
Reference Range
| Liver Kidney Microsome IgG Autoabs | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal: < 1:20 |
Special Info
Severely hemolyzed or lipemic specimens are unacceptable. This test is New York DOH approved.
Clinical Info
Differential evaluation of autoimmune liver disease of unknown etiology, especially autoimmune hepatitis (AIH) of childhood onset. Liver-Kidney Microsome IgG antibody (anti-LKM), as detected by indirect immunofluorescent antibody (IFA) techniques, may be observed in patients with autoimmune hepatitis type 2 (AIH-2), AIH-2 associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), viral hepatitis C or D, and some forms of drug-induced hepatitis. This IFA does not differentiate among the four types of LKM antibodies (LKM-1, LKM-2, LKM-3, and a fourth type that recognizes CYP1A2 and CYP2A6 antigens). Of these, anti-LKM-1 (cytochrome P450IID6) IgG antibodies are considered specific for AIH-2.