Lupus Anticoagulant Diagnostic Interpretive Panel
Test Mnemonic
LUPUSP
CPT Codes
- 85670 - QTY (1)
- 86147 - QTY (3)
- 85610 - QTY (1)
- 85390 - QTY (1)
- 86146 - QTY (2)
- 85520 - QTY (1)
- 85730 - QTY (1)
- 85730 - QTY (1)
Aliases
- Lupus Anticoag Panel
Includes
- APTT
- Anticardiolipin Ab IgG, IgM and IgA
- Beta 2 Glycoproteins IgG and IgM
- Prothrombin Time (PT)
- APTT Screen
- Thrombin Time
- Anti Xa Inhibitor Assay
- Dilute Russell Viper Venom Time (DRVVT)
- Hexagonal Phase Phospholipid Neutralization (Staclot)
- Platelet Neutralization (PNP)
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Frozen | ||
| 5 mL | Plasma | Sodium citrate (Lt. Blue) | Centrifuge, aliquot and freeze ASAP. | Collection tubes must be filled to total fill volume. Inadequately filled tubes will be rejected. Non-testing sites: Centrifuge samples; Aliquot plasma into a separate tube and label with Epic Beaker labels. Specimens should be frozen (-20C or colder). Indicate on each tube as plasma. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.2 mL | Serum | ||||
| 2.5 mL | Plasma |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 4 hours - Main campus: ACCEPTABLE for Whole Blood. (Must be delivered ambient to testing lab less than 4 hours post collection.) Non-Testing Sites: UNACCEPTABLE. |
| Refrigerated | Unacceptable |
| Frozen | For Non-Testing sites, Frozen Plasma is ACCEPTABLE. (Centrifuge samples, then aliquot plasma into a separate tube and label with Epic Beaker labels. Specimens should be frozen at -20° C and they are stable for 2 weeks. Specimens frozen at -70° C are stable for up to 6 months. |
Days Performed
Mon - Fri
Turnaround Time
3 - 5 days
Methodology
| Name | Description |
|---|---|
| Refer to individual components |
Reference Range
Special Info
3.2% sodium citrate is the preferred anticoagulant recommended by NCCLS. Patient preparation: Discontinue heparin therapy for 2 days prior to collection. If tests are abnormal, the following tests may be ordered and billed: PTT Mixing Study (85730), Factor II (85210), Factor V (85220), Factor VII (85230), Factor X (85260), Factor VIII (85247), Von Willebrand Factor Antigen (85246), Ristocetin Co-factor (85245), Factor IX Assay (85250), Factor XI Assay (85270), Factor XII Assay (85280), Reptilase Time (85635), D-Dimer (85379), Fibrinogen Ag (85385), Fibrinogen (85384), Bethesda Assay (85335) and Factor VIII Chromogenic (85240). Sample must be accompanied by the completed Clinical History Form for Hemostasis and Thrombosis Evaluation.
Clinical Info
Evaluation of acquired hypercoagulable states and detection of Lupus anticoagulant and Antiphospholipid antibodies