Methylmalonic Acid (MMA) Quantitative, Urine
Test Mnemonic
UMMA
CPT Codes
- 83921 - QTY (1)
Aliases
- Methylmalonic Acid (MMA) Quantitation, Urine
- MMA Urine
Includes
- Creatinine Ur mg/dL
- Creatinine Ur mg/dy
- Methylmalonic Acid umol/L
- Methylmalonic Acid mmol/mol
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4 mL | Urine, random | Clean container | Frozen, ASAP |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4 mL | Urine, 24-hour (well-mixed) | Clean container | Frozen, ASAP | Frozen, ASAP |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Unacceptable |
| Refrigerated | 1 week |
| Frozen | 1 month |
Days Performed
Sun - Sat
Turnaround Time
2 - 6 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
Reference Range
| Methylmalonic Acid mmol/mol | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.0 - 3.6 | mmol/mol crt |
Special Info
Indicate total volume on requisition. This test is New York DOH approved.
Clinical Info
Elevated urinary methylmalonic acid is an early and sensitive indicator of vitamin B12 (cobalamin) deficiency. This test can also be used to monitor patients with methylmalonic aciduria; Diagnosis of methylmalonic aciduria requires an organic acid panel and appropriate clinical history.