Motor and Sensory Neuropathy Evaluation with Reflex to Titer and Neuronal Immunoblot
Test Mnemonic
SENMOT
CPT Codes
- 83516 - QTY (7)
- 86255 - QTY (1)
Includes
- Asialo-GM1 Antibodies, IgG/IgM
- GM1 Antibodies, IgG/IgM
- GD1a Antibodies, IgG/IgM
- GD1b Antibodies, IgG/IgM
- GQ1b Antibodies, IgG/IgM
- SGPG Antibody, IgM
- MAG Antibody, IgM Elisa
- Purkinje Cell/Neuronal Nuclear IgG Scrn
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Serum | SST (Gold) | Refrigerated | Separate serum from cells ASAP or within 2 hours of collection. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 24 hours |
| Refrigerated | After separation from cells: 2 weeks |
| Frozen | After separation from cells: 1 year |
Days Performed
Thu
Turnaround Time
2 - 10 days
Methodology
| Name | Description |
|---|---|
| Immunoblot (IB), Qualitative | |
| Semi Quantitative Enzyme Linked Immunosorbent Assay | |
| Semi-Quantitative Indirect Fluorescent Antibody |
Reference Range
| Asialo-GM1 Antibodies, IgG/IgM | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative: 29 IV or less | Equivocal: 30-50 IV | Positive: 51-100 IV | Strong Positive: 101 IV or greater | ||
| GD1a Antibodies, IgG/IgM | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative: 29 IV or less | Equivocal: 30-50 IV | Positive: 51-100 IV | Strong Positive: 101 IV or greater | ||
| GD1b Antibodies, IgG/IgM | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative: 29 IV or less | Equivocal: 30-50 IV | Positive: 51-100 IV | Strong Positive: 101 IV or greater | ||
| GM1 Antibodies, IgG/IgM | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative: 29 IV or less | Equivocal: 30-50 IV | Positive: 51-100 IV | Strong Positive: 101 IV or greater | ||
| GQ1b Antibodies, IgG/IgM | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative: 29 IV or less | Equivocal: 30-50 IV | Positive: 51-100 IV | Strong Positive: 101 IV or greater | ||
| MAG Antibody, IgM Elisa | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Less than 1000 TU | ||||
| SGPG Antibody, IgM | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Less than 1.00 | IV |
Special Info
Reflex Algorithm: Purkinje Cell (PCCA) antibody and Neuronal Nuclear (ANNA) antibody IgG are screened by IFA. If the IFA screen is indeterminate, then a Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot is performed at an additional cost. If the IFA screen is positive at 1:10 or greater, then a PCCA/ANNA antibodies titer and Neuronal Nuclear Antibodies (Hu, Ri, Yo, and Tr/DNER) IgG by Immunoblot are performed at an additional cost. Contaminated, heat-inactivated, hemolyzed, severely icteric, or lipemic specimens will be rejected. This test is New York state approved.
Clinical Info
This test aids in diagnosis of combined motor/sensory neuropathy when malignancy, other than plasma cell dyscrasia, is suspected.