Mycophenolic Acid and Metabolite




Test Mnemonic

MYCMET

CPT Codes

  • 80180 - QTY (1)

Includes

  • Mycophenolic Acid
  • Mycophenolic Acid Glucuronide

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumNo additive (Red) RefrigeratedSeparate serum from cells within 2 hours of collection.

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLPlasmaEDTA (Lavender) RefrigeratedSeparate plasma from cells within 2 hours of collection.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.1 mL     

Stability

Environmental Condition Description
AmbientAfter separation from cells: 6 weeks
RefrigeratedAfter separation from cells: 6 weeks
FrozenAfter separation from cells: 11 months

Days Performed

Sun - Sat

Turnaround Time

2 - 5 days

Methodology

Name Description
Quantitative Liquid Chromatography - Tandem Mass Spectrometry 

Reference Range

Myc.Acid Glucoronide
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormal35.0 - 100.0ug/mL
Mycophenolic Acid
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormal1.0 - 3.5ug/mL

Special Info

Timing of specimen collection: Pre-dose (trough) draw at steady state concentration. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution) are unacceptable. Whole blood will also be rejected. This test is New York DOH approved.

Clinical Info

Therapeutic monitoring for individuals taking mycophenolate. The therapeutic range is based on serum pre-dose (trough) draw at steady state concentration. A proposed therapeutic range is 1.0 - 3.5 ug/mL for a 2 g/day dose. A 3 g/day dose may have plasma concentrations up to 5.0 ug/mL. Trough concentrations between 2.0 - 4.0 ug/mL have been suggested to maximize efficacy and minimize adverse effects. Mycophenolic acid glucuronide is an inactive metabolite and a range of 35.0 - 100.0 ug/mL indicates normal metabolism. During the first two weeks of transplantation, mycophenolic acid glucuronide concentrations are typically 100 - 250 ug/mL. Adverse effects of toxicity include abdominal pain, peripheral edema, cardiac abnormalities, hypertension and electrolyte disturbances.