Neuronal Nuclear Abs IgG by Immunoblot
Test Mnemonic
HURIYO
CPT Codes
- 84182 - QTY (4)
LOINC ®
35278-1
Aliases
- Neuronal Nuclear Abs (Hu, Ri, Yo, Tr/DNER) IgG, Immunoblot
Includes
- Neuronal nuclear Ab Hu, IgG
- Neuronal nuclear Ab Ri, IgG
- Neuronal nuclear Ab Yo, IgG
- Neuronal nuclear Ab Tr/DNER, IgG
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Refrigerated | Separate serum from cells ASAP or within 2 hours of collection and transfer into a standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.3 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | After separation from cells: 2 weeks |
| Ambient | After separation from cells: 48 hours |
| Frozen | After separation from cells: 1 month |
Days Performed
Mon, Thu, Sat
Turnaround Time
2 - 5 days
Methodology
| Name | Description |
|---|---|
| Immunoblot (IB), Qualitative |
Reference Range
| Neuronal Nuc Ab, Hu | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Negative | ||||
| Neuronal Nuc Ab, Ri | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Negative | ||||
| Neuronal Nuc Ab, Tr/DNER | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Negative | ||||
| Neuronal Nuc Ab, Yo | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Negative |
Special Info
Plasma will be rejected. Grossly hemolyzed, heat-inactivated, contaminated, or lipemic specimens are unacceptable.
Clinical Info
This assay detects IgG antineuronal antibodies to Hu, Ri, Yo and Tr (DNER) antigens. Antineuronal antibodies serve as markers that aid in discriminating between a true paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with fallopian tube and breast cancer in adults and neuroblastoma in children. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer. Anti-Tr(DNER) is associated with Hodgkin’s lymphoma. Presence of one or more of these antineuronal antibodies supports a clinical diagnosis of PND and should lead to a focused search for the underlying neoplasm.