Neuronal Nuclear Antibodies (Hu, Ri, Yo, Tr/DNER) IgG by Immunoblot, Serum
Test Mnemonic
HURIYO
CPT Codes
- 84182 - QTY (4)
LOINC ®
35278-1
Includes
- Neuronal nuclear Ab Hu, IgG
- Neuronal nuclear Ab Ri, IgG
- Neuronal nuclear Ab Yo, IgG
- Neuronal nuclear Ab Tr/DNER, IgG
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Refrigerated | Separate serum from cells ASAP or within 2 hours of collection. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.3 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | After separation from cells: 2 weeks |
| Ambient | After separation from cells: 48 hours |
| Frozen | After separation from cells: 1 month |
Days Performed
Mon, Thu, Sat
Turnaround Time
2 - 5 days
Methodology
| Name | Description |
|---|---|
| Immunoblot (IB), Qualitative |
Reference Range
| Neuronal Nuc Ab, Hu | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Negative | ||||
| Neuronal Nuc Ab, Ri | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Negative | ||||
| Neuronal Nuc Ab, Tr/DNER | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Negative | ||||
| Neuronal Nuc Ab, Yo | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Negative |
Special Info
This test may be a reflex from Motor and Sensory Neuropathy Evaluation with Reflex to Titer and Neuronal Immunoblot (SENMOT) or Sensory Neuropathy Antibody Panel with Reflex to Titer and Neuronal Immunoblot (SENNRO). Grossly hemolyzed, heat-inactivated, contaminated, or lipemic specimens will be rejected.
Clinical Info
This assay detects IgG antineuronal antibodies to Hu, Ri, Yo and Tr (DNER) antigens. Antineuronal antibodies serve as markers that aid in discriminating between a true paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-Hu (antineuronal nuclear antibody, type I) is associated with small cell lung cancer. Anti-Ri (antineuronal nuclear antibody, type II) is associated with fallopian tube and breast cancer in adults and neuroblastoma in children. Anti-Yo (anti-Purkinje cell cytoplasmic antibody) is associated with ovarian and breast cancer. Anti-Tr(DNER) is associated with Hodgkin’s lymphoma. Presence of one or more of these antineuronal antibodies supports a clinical diagnosis of PND and should lead to a focused search for the underlying neoplasm.