Prenatal Quad Screen




Test Mnemonic

QUAD4

CPT Codes

  • 81511 - QTY (1)

LOINC ®

49092-0

Aliases

  • AFP Quad Check
  • AFP4

Includes

  • Patient's AFP
  • Estimated Due Date
  • MoM for DIA
  • Patient's DIA
  • MoM for AFP
  • Maternal Screen Interpretation
  • Specimen
  • Dating
  • Insulin Req Maternal Diabetes
  • Family Hx Neural Tube Defect
  • Maternal Race
  • Number of Fetuses
  • Maternal Age At Delivery
  • Patient's uE3
  • MoM for uE3
  • Family History of Aneuploidy
  • Smoking
  • EER Maternal Serum, Quad
  • Patient's hCG, 2nd Trimester
  • hCG MoM, 2nd Trimester
  • Gestational Age Calculated at Collection
  • Maternal Weight

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
3 mLSerumSST (Gold) RefrigeratedSeparate serum from cells ASAP or within 2 hours of collection. Transfer serum to standard aliquot tube. Submit a Maternal Serum Testing Patient History Form with specimen. Complete clinical and demographic information is required for reporting. Specimen must be drawn between 14 weeks, 0 days and 24 weeks, 6 days gestation. The recommended time for maternal serum screening is 16 to 18 weeks gestation.

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
3 mLSerumNo additive (Red) RefrigeratedSeparate serum from cells ASAP or within 2 hours of collection. Transfer serum to standard aliquot tube. Submit a Maternal Serum Testing Patient History Form with specimen. Complete clinical and demographic information is required for reporting. Specimen must be drawn between 14 weeks, 0 days and 24 weeks, 6 days gestation. The recommended time for maternal serum screening is 16 to 18 weeks gestation.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mL     

Stability

Environmental Condition Description
AmbientAfter separation from cells: 72 hours
RefrigeratedAfter separation from cells: 2 weeks
FrozenAfter separation from cells: 1 year (avoid repeated freeze/thaw cycles)

Days Performed

Sun - Sat

Turnaround Time

3 - 4 days

Methodology

Name Description
Quantitative Chemiluminescent Immunoassay 

Reference Range

AFP (maternal)
Sex Age From Age To Type Range Range Unit
       Refer to report 

Special Info

Hemolyzed specimens are unacceptable. This test is New York DOH approved.

Clinical Info

Second-trimester screening test for trisomy 21 (Down syndrome), trisomy 18, and open neural tube defects.