Protein C Functional
Test Mnemonic
PRCFUN
CPT Codes
- 85303 - QTY (1)
LOINC ®
27819-2
Aliases
- Protein C Activity
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Plasma | Sodium citrate (Lt. Blue) | Frozen |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | citrated plasma separated from cells stable for 8 hours |
| Frozen | frozen plasma up to 1 month at -20 C and up to 6 months at -70 C |
| Refrigerated | unacceptable |
Days Performed
Mon - Fri
Turnaround Time
1 - 3 days
Methodology
| Name | Description |
|---|---|
| Chromogenic |
Reference Range
| Protein C Functional | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Days | 1 Days | Normal | 20 - 61 | % | 2 Days | 5 Days | Normal | 24 - 74 | % | 6 Days | 30 Days | Normal | 25 - 75 | % | 1 Months | 3 Months | Normal | 33 - 92 | % | 4 Months | 11 Months | Normal | 44 - 93 | % | 1 Years | 5 Years | Normal | 48 - 106 | % | 6 Years | 10 Years | Normal | 53 - 107 | % | 11 Years | 16 Years | Normal | 65 - 128 | % | 17 Years | 99 Years | Normal | 76 - 147 | % |
Special Info
3.2% sodium citrate is the preferred anticoagulant recommended by CLSI. If protein C functional assay is decreased, suggest ordering protein C immunologic.
Clinical Info
For use in the evaluation of hypercoagulable states due to congenital or acquired protein C deficiency. This is a functional chromogenic assay that detects changes in protein C functionality in plasma. Protein C levels can be lowered by coumadin, vitamin K deficiency, liver disease and DIC.