Protein C Functional
Test Mnemonic
PRCFUN
CPT Codes
- 85303 - QTY (1)
LOINC ®
27819-2
Aliases
- Protein C Activity
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | Sodium citrate (Lt. Blue) | Centrifuge, aliquot and freeze ASAP. | Collection tube must be filled to total fill volume. Inadequately filled tubes will be rejected. Non-testing sites: Centrifuge sample, aliquot plasma into a separate tube and label with Epic Beaker labels. Specimens should be frozen (-20C or colder). |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | citrated plasma separated from cells stable for 8 hours |
| Frozen | frozen plasma up to 1 month at -20 C and up to 6 months at -70 C |
| Refrigerated | unacceptable |
Days Performed
Mon - Fri
Turnaround Time
1 - 3 days
Methodology
| Name | Description |
|---|---|
| Chromogenic |
Special Info
3.2% sodium citrate is the preferred anticoagulant recommended by CLSI. If protein C functional assay is decreased, suggest ordering protein C immunologic.
Clinical Info
For use in the evaluation of hypercoagulable states due to congenital or acquired protein C deficiency. This is a functional chromogenic assay that detects changes in protein C functionality in plasma. Protein C levels can be lowered by coumadin, vitamin K deficiency, liver disease and DIC.