PTT Incubated Mixing Study




Test Mnemonic

PTTIM

CPT Codes

  • 85730 - QTY (1)
  • 85610 - QTY (1)
  • 85670 - QTY (1)
  • 85520 - QTY (1)
  • 85390 - QTY (1)

Aliases

  • APTT Mixing Study
  • CAC
  • CACLA
  • Circulating Anticoagulant
  • PTT Correction Study
  • PTT Mixing Study
  • APTT Incubated Mixing Study

Includes

  • PT Screen
  • APTT Screen
  • Thrombin Time
  • Heparin Anti Xa Assay

Performing Laboratory

n/a


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
6 mLPlasmaSodium citrate (Lt. Blue) Centrifuge, aliquot and freeze ASAP.Collection tubes must be filled to total fill volume. Inadequately filled tubes will be rejected. Non-testing sites: Centrifuge samples; Aliquot plasma into a separate tube and label with Epic Beaker labels. Specimens should be frozen (-20C or colder).

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2 mL    Minimum is 2 mL of plasma. NOTE: If only the minimum volume is received, some reflex testing may not be able to be performed.

Stability

Environmental Condition Description
AmbientMain campus: ACCEPTABLE for Whole Blood. (Must be delivered ambient to testing lab less than 4 hours post collection.) Non-Testing Sites: UNACCEPTABLE.
RefrigeratedUnacceptable
FrozenFor Non-Testing sites, Frozen Plasma is ACCEPTABLE. (Centrifuge samples, then aliquot plasma into a separate tube and label with Epic Beaker labels. Specimens should be frozen (-20° C or colder) and they are stable for 2 weeks. (6 months at -70 C)

Days Performed

Mon - Fri

Turnaround Time

1 - 3 days

Methodology

Name Description
Clot Detection 

Reference Range

APTT Screen
Sex Age From Age To Type Range Range Unit
   Days1 DaysNormal28.2-47.4sec
 1 Months3 MonthsNormal21.7-43.5sec
 2 Days5 DaysNormal22.9-52.0sec
 6 Days30 DaysNormal23.1-48.0sec
 4 Months11 MonthsNormal25.3-37.3sec
 1 Years5 YearsNormal21.3-31.6sec
 6 Years10 YearsNormal23.1-31.6sec
 11 Years16 YearsNormal23.1-32.5sec
 17 Years99 YearsNormal24.0-35.1sec
PT Screen
Sex Age From Age To Type Range Range Unit
   Days1 DaysNormal< 14.9sec
 1 Months3 MonthsNormal< 13.3sec
 2 Days5 DaysNormal< 14.3sec
 6 Days30 DaysNormal< 13.4sec
 4 Months11 MonthsNormal< 13.0sec
 1 Years5 YearsNormal< 10.7sec
 6 Years10 YearsNormal< 11.3sec
 11 Years16 YearsNormal< 11.2sec
 17 Years99 YearsNormal< 13.1sec
Thrombin Time
Sex Age From Age To Type Range Range Unit
   Days1 DaysNormal< 17.3sec
 2 Days5 DaysNormal< 17.9sec
 6 Days30 DaysNormal< 17.9sec
 1 Months3 MonthsNormal< 18.2sec
 4 Months11 MonthsNormal< 19.1sec
 1 Years999 YearsNormal< 18.6sec

Special Info

If tests are abnormal in the panel, the following tests may be ordered and billed: PTT Immediate and 1 Hour Incubated Mix (85732 x2), Factor II (85210), Factor V (85220), Factor VII (85230), Factor X (85260), Factor VIII (85247), Factor VIII Chromogenic (85240), Factor IX Assay (85250), Factor XI Assay (85270), Factor XII Assay (85280), Reptilase Time (85635), D-Dimer (85379), von Willebrand Factor Antigen (85246), Platelet Neutralization (85597), Ristocetin Co-Factor (85245), Bethesda Inhibitor (85335), Dilute Russell Viper Venom Time (85613 x2), Hexagonal Phase Phospholipid Neutralization (85730 & 85598), Fibrinogen (85384) & Fibrinogen Ag (85385).

Clinical Info

To distinguish a coagulation factor deficiency from an inhibitor.