Ribosomal P Protein IgG Autoantibodies
Test Mnemonic
RIBPRO
CPT Codes
- 83516 - QTY (1)
Includes
- Ribosomal P Protein Antibody
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Refrigerated | Separate serum from cells ASAP or within 2 hours of collection and transfer into standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.2 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 48 hours |
| Refrigerated | After separation from cells: 2 weeks |
| Frozen | After separation from cells: 1 year (Avoid repeated freeze/thaw cycles) |
Days Performed
Sun - Sat
Turnaround Time
2 - 4 days
Methodology
| Name | Description |
|---|---|
| Semi-Quantitative Multiplex Bead Assay |
Reference Range
| Ribosomal P Protein IgG Autoantibodies | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | < or = 29 Negative | AU/mL | Normal | 30 - 40 Equivocal | AU/mL | Normal | > or = 41 Positive | AU/mL |
Special Info
Plasma or other body fluids are unacceptable. Bacterially contaminated or severely lipemic specimens will be rejected. This test is New York DOH approved.
Clinical Info
Autoantibodies reacting with cytoplasmic ribosomes are highly specific for systemic lupus erythematosus. Ribosomal-P antibodies are found in approximately 12% of patients with systemic lupus erythematosus (SLE) and in 90% of patients with lupus psychosis; titers often increase more than fivefold during and before active phases of psychosis.