Risperidone & Metabolite
Test Mnemonic
RISPER
CPT Codes
- 80342 - QTY (1)
- G0480 - QTY (1)
LOINC ®
9393-0
Includes
- Risperidone
- 9-Hydroxyrisperidone
- Risperidone + 9-Hydroxyrisperidone-Total
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Refrigerated | Pre-dose (trough) draw - At steady state concentration. Do not use serum separator tubes. Separate serum from cells within 2 hours of collection and transfer into standard aliquot tube. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | EDTA (Lavender) | Refrigerated | Pre-dose (trough) draw - At steady state concentration. Separate plasma from cells within 2 hours of collection and transfer into standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | 2 weeks |
| Ambient | 2 weeks |
| Frozen | 2 months |
Days Performed
Mon, Wed, Sat
Turnaround Time
2 - 8 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
Reference Range
| Risperidone & Metabolite | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Therapeutic range (Risperidone) 20-60 ng/mL | Therapeutic range (9-hydroxyrisperidone (Paliperidone)) 20-60 ng/mL | Toxic range (Risperidone and Metabolite) Greater than 120 ng/mL |
Special Info
Patient Prep: Pre-dose (trough) draw - At steady state concentration. Gel separator tubes are not acceptable. Whole blood specimens will be rejected. Light blue (citrate) or yellow (SPS or ACD solution) tubes are unacceptable. This test is New York DOH approved.
Clinical Info
Optimize drug therapy and monitor patient adherence. This test detects risperidone (parent) and paliperidone (9-hydroxyrisperidone, metabolite). The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Adverse effects to risperidone therapy may include headache, nausea, dizziness, tachycardia, orthostatic hypotension and dyskinesia.