Sertraline
Test Mnemonic
SERTRA
CPT Codes
- 80332 / G0480 - QTY (1)
LOINC ®
13579-8
Aliases
- Lustral
- Zoloft
Includes
- Sertraline Serum or Plasma
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Refrigerated | Do not use serum separator tubes. Separate serum from cells within 2 hours of collection. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | EDTA (Lavender) | Refrigerated | Separate plasma from cells within 2 hours of collection. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 24 hours |
| Refrigerated | After separation from cells: 2 weeks |
| Frozen | After separation from cells: 4 months |
Days Performed
Wed
Turnaround Time
2 - 9 days
Methodology
| Name | Description |
|---|---|
| Quantitative Liquid Chromatography - Tandem Mass Spectrometry |
Reference Range
| Sertraline | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | Therapeutic range: 30 - 200 | ng/mL | Years | 99 Years | Normal | Toxic: Greater than 300 | ng/mL |
Special Info
Specimen should be collected prior to next dose (trough) - at steady state concentration. Whole blood is unacceptable. Gel separator tubes, light blue (citrate) tubes, and SPS or ACD solution (yellow) tubes will be rejected. This test is New York DOH approved.
Clinical Info
Sertraline is a selective serotonin reuptake inhibitor antidepressant drug indicated for the treatment of major depressive disorder, obsessive-compulsive disorder, posttraumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. Sertraline doses range from 50-200 mg/day to produce serum concentration that range from 30-200 ng/mL. Dosing above 200 mg/day may increase the risk of adverse effects. Adverse effects may include dry mouth, headache, dizziness, fatigue, somnolence, tremor, nausea, and diarrhea. The risk of serotonin syndrome is increased with concomitant use of other serotonergic drugs. Concomitant use of sertraline with anticoagulants and nonsteroidal anti-inflammatory drugs may increase the risk of bleeding.