Soluble Transferrin Receptor
Test Mnemonic
STRANS
CPT Codes
- 84238 - QTY (1)
LOINC ®
33210-6
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Refrigerated |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Refrigerated |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.3 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | 14 days |
| Frozen | 30 days |
| Ambient | 24 hours |
Days Performed
Mon, Wed, Fri
Turnaround Time
2 - 3 days
Methodology
| Name | Description |
|---|---|
| Immunoenzymatic Assay |
Reference Range
| Soluble transferrin receptor | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 1 Years | Normal | 13.28 - 26.96 | nmol/L | 1 Years | 2.5 Years | Normal | 18.56 - 35.77 | nmol/L | 2.5 Years | 14 Years | Normal | 13.96 - 28.32 | nmol/L | 14 Years | 18 Years | Normal | 10.70 - 22.76 | nmol/L | 18 Years | Normal | 12.16 - 27.25 | nmol/L |
Clinical Info
The soluble transferring receptor (sTfR) assay is intended to: 1) Aid in the diagnosis of Iron Deficiency Anemia (IDA) and 2) Assist in the differential diagnosis of IDA and Anemia of Chronic Disease (ACD). Iron deficiency causes overexpression of the transferrin receptor and elevated sTfR concentrations. While ferritin is the traditional marker for assessment of iron deficiency, it can be influenced by inflammation and chronic disease, whereas sTfR levels are minimally affected by these processes.
Clinical Limitation
sTfR levels may be elevated in conditions associated with hyperplastic erythropoiesis (e.g., hemolytic anemia, β-thalassemia, polycythemia) and decreased in conditions associated with hypoplastic erythropoiesis (e.g., chronic renal failure, aplastic anemia, or post-transplant anemia). While sTfR is minimally affected by inflammation and chronic disease, it should be interpreted in conjunction with other iron status indicators, such as ferritin, for optimal diagnostic accuracy.