Sulfonylurea Hypoglycemics




Test Mnemonic

SULFON

CPT Codes

  • 80377 - QTY (1)

Aliases

  • Hypoglycemia Panel

Includes

  • Rosiglitazone
  • Chlorpropamide
  • Glimepiride
  • Glipizide
  • Pioglitazone
  • Glyburide
  • Nateglinide
  • Repaglinide
  • Tolazamide
  • Tolbutamide

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumNo additive (Red) FrozenDo not use serum separator tubes. Separate serum from cells ASAP or within 2 hours of collection. Separate specimens must be submitted when multiple tests are ordered.

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLPlasmaPotassium oxalate/sodium fluoride (Gray) FrozenDo not use plasma separator tubes. Separate plasma from cells ASAP or within 2 hours of collection. Separate specimens must be submitted when multiple tests are ordered.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.3 mL     

Stability

Environmental Condition Description
Frozen24 months
Refrigerated28 days
Ambient48 hours

Days Performed

Varies

Turnaround Time

5 - 7 days

Methodology

Name Description
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) 

Reference Range

Chlorpropamide
Sex Age From Age To Type Range Range Unit
       Cutoff: 100 ng/mL 
Glimepiride
Sex Age From Age To Type Range Range Unit
       Cutoff: 5 ng/mL 
Glipizide
Sex Age From Age To Type Range Range Unit
       Cutoff: 5 ng/mL 
Glyburide
Sex Age From Age To Type Range Range Unit
       Cutoff: 5 ng/mL 
Nateglinide
Sex Age From Age To Type Range Range Unit
       Cutoff: 5 ng/mL 
Repaglinide
Sex Age From Age To Type Range Range Unit
       Cutoff: 5 ng/mL 
Tolazamide
Sex Age From Age To Type Range Range Unit
       Cutoff: 100 ng/mL 
Tolbutamide
Sex Age From Age To Type Range Range Unit
       Cutoff: 100 ng/mL 

Special Info

Do not use serum separator tubes. Separate specimens must be submitted when multiple tests are ordered. This test is New York DOH approved.

Clinical Info

Preferred test for evaluating if etiology of hypoglycemia is sulfonylurea ingestion. The assay is used to evaluate hypoglycemia that may be caused from the ingestion of sulfonylurea drugs. Hypoglycemic drugs are detected if the drug concentration is greater than the limit of detection (cut-off). The presence of hypoglycemic drug(s) indicates a recent ingestion.