Supersaturation Profile, 24 Hour Urine | Cleveland Clinic Laboratories

Supersaturation Profile, 24 Hour Urine Print

Test Mnemonic

SSAT24

CPT Codes

84540 - QTY (1)
84560 - QTY (1)
82140 - QTY (1)
82340 - QTY (1)
82436 - QTY (1)
82507 - QTY (1)
82570 - QTY (1)
83935 - QTY (1)
83945 - QTY (1)
83986 - QTY (1)
84105 - QTY (1)
84392 - QTY (1)
84300 - QTY (1)
84133 - QTY (1)
83735 - QTY (1)

Includes

Calcium Oxalate crystal
Brushite crystal
Hydroxyapatite crystal
Uric Acid crystal
Potassium
Sodium
Calcium
Magnesium
Chloride
Phosphorus
Sulfate
Citrate Excretion
Oxalate
pH
Uric Acid
Creatinine
Osmolality
Ammonium
Urea Nitrogen
Protein Catabolic Rate

Performing Laboratory

Mayo Clinic Dpt of Lab Med & Pathology

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
35 mL	Urine, 24-hour (well-mixed)	Clean container (No preservatives)	Refrigerate during collection.	Refrigerated	Refrigerate specimen during and after collection. Specimen pH should be between 4.5-8.0 and will stay in this range if kept refrigerated. Specimens with pH >8 indicate bacterial contamination, and testing will be cancelled. Do not attempt to adjust pH as it will adversely affect results. 24-hour volume is required. Patients height in centimeters and weight in kilograms are required if patient is less than 18 years old.

Minimum Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
25 mL

Stability

Environmental Condition	Description
Ambient	3 days
Frozen	14 days
Refrigerated	14 days

Days Performed

Sun - Sat

Turnaround Time

3 - 6 days

Methodology

Name	Description
Colorimetric Enzyme Assay
Enzymatic
Freezing Point Depression
Photometric
Uricase
Colorimetric Endpoint
Calculation
High-Performance Ion Chromatography (HPIC)
Kinetic UV Assay
pH Meter
Potentiometric, Indirect Ion-Selective Electrode (ISE)

Reference Range

Ammonium, 24Hr, Ur
Sex	Age From	Age To	Type	Range	Range Unit
	18 Years	77 Years	Normal	15 - 56	mmol/24 hr
	Years	17 Years	Normal	Not established
	78 Years	99 Years	Normal	Not established
Brushite Crystal
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	Reference Mean = 0.21	DG
Calcium Oxalate Crystal
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	Reference Mean = 1.77	DG
Calcium,Urine
Sex	Age From	Age To	Type	Range	Range Unit
Male	18 Years	99 Years	Normal	< 250	mg/24 hrs
Female	18 Years	99 Years	Normal	< 200	mg/24 hrs
	Years	17 Years	Normal	Not established
Chloride,Urine
Sex	Age From	Age To	Type	Range	Range Unit
	18 Years	99 Years	Normal	34 - 286	mmol/24 hr
	Years	17 Years	Normal	Not established
Creatinine,Urine
Sex	Age From	Age To	Type	Range	Range Unit
Male	18 Years	99 Years	Normal	930 - 2,955	mg/24 hrs
Female	18 Years	99 Years	Normal	603 - 1,783	mg/24 hrs
	Years	17 Years	Normal	Not established
Hydroxyapatite Crystal
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	Reference Mean = 3.96	DG
Magnesium,Urine
Sex	Age From	Age To	Type	Range	Range Unit
	18 Years	99 Years	Normal	51 - 269	mg/24 hrs
	Years	17 Years	Normal	Not established	.
Osmolaltiy, 24Hr, Ur
Sex	Age From	Age To	Type	Range	Range Unit
	Months	11 Months	Normal	50 - 750	mOsm/kg
	1 Years	99 Years	Normal	150 - 1,150	mOsm/kg
Oxalate,U mg/spec
Sex	Age From	Age To	Type	Range	Range Unit
	16 Years	99 Years	Normal	9.7 - 40.5	mg/24 hrs
		15	Normal	Not established
Oxalate,U mmol/spec
Sex	Age From	Age To	Type	Range	Range Unit
	16 Years	99 Years	Normal	0.11 - 0.46	mmol/24 hr
	Years	15 Years	Normal	Not established
pH,Urine
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	4.5 - 8.0	.
Phosphorus,Urine
Sex	Age From	Age To	Type	Range	Range Unit
	18 Years	99 Years	Normal	266 - 1,797	mg/24 hrs
	Years	17 Years	Normal	Not established
Potassium,Urine
Sex	Age From	Age To	Type	Range	Range Unit
	18 Years	99 Years	Normal	16-105	mmol/24 hr
	Years	17 Years	Normal	Not established
Protein Catabolic Rate, Ur
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	56 - 125	g/24 hour
Sodium,Urine
Sex	Age From	Age To	Type	Range	Range Unit
	18 Years	99 Years	Normal	22-328	mmol/24 hr
	Years	17 Years	Normal	Not established
Sulfate,Urine
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	7 - 47	mmol/24 hr
Urea Nitrogen
Sex	Age From	Age To	Type	Range	Range Unit
	18 Years	99 Years	Normal	7 - 42	g/24 hrs
	Years	17 Years	Normal	Not established
Uric Acid Crystal
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	Reference Mean = 1.04	DG
Uric Acid,Urine
Sex	Age From	Age To	Type	Range	Range Unit
Male	18 Years	99 Years	Normal	200 - 1,000	mg/24 hrs
Female	18 Years	99 Years	Normal	250 - 750	mg/24 hrs
	Years	17 Years	Normal	Not established

Special Info

Refrigerate specimen during and after collection. Specimens with pH > 8.0 will be rejected. Do not attempt to adjust pH as it will adversely affect results. This test is New York DOH approved.

Clinical Info

This test is useful in diagnosis and management of patients with renal lithiasis by predicting the likely composition of the stone in patients who have a radiopaque stone or for whom stone analysis is not available. Results may help in designing a treatment program, identify specific risk factors for stones, monitor the effectiveness of therapy, evaluate kidney excretion of acid and urine pH and estimate a patient's protein intake. Creatinine: To convert to mg/kg/24 hours, divide the mg/24 hour result by body weight in kg. CAUTIONS: Urine is often supersaturated with respect to the common crystalline constituents of stones, even in non-stone formers. Individual interpretation of the supersaturation values in light of the clinical situation is critical. In particular, treatment may reduce the supersaturation with respect to one crystal type but increase the supersaturation with respect to another. Therefore, the specific goals of treatment must be considered when interpreting the test results.