Tetrahydrobiopterin & Neopterin, CSF
Test Mnemonic
TBIOPT
CPT Codes
- 83789 - QTY (1)
Includes
- Tetrahydrobiopterin
- Neopterin
Performing Laboratory
Medical Neurogenetics
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4.5 mL | Cerebrospinal fluid (CSF) | Set of 5 MNG Collection Tubes | Frozen | CSF should be collected from the first drop into the containers in the order indicated. Fill each tube to the marked line (0.5 mL in tube 1; 1.0 mL in tubes 2, 3, 4, and 5). Place specimens on ice after collection. If specimen is blood contaminated, the tubes should be centrifuged immediately (prior to freezing) and the clear CSF transferred to new similarly labeled tubes then frozen ASAP at -80 C. Call Client Services at 216-444-5755 or 800-628-6816 to obtain sample collection tubes. |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Unacceptable |
| Refrigerated | Unacceptable |
| Frozen | Indefinitely |
Days Performed
Tue - Fri
Turnaround Time
15 - 17 days
Methodology
| Name | Description |
|---|---|
| High Performance Liquid Chromatography with Fluorescence Detection (HPLC-FL) | |
| High Performance Liquid Chromatography with Electrochemical Detection |
Reference Range
| Neopterin | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 5 Years | Normal | 7-65 | nmol/L | 5 Years | 10 Years | Normal | 7-40 | nmol/L | 10 Years | 15 Years | Normal | 8-33 | nmol/L | Adults: 8-28 nmol/L |
| Tetrahydobiopterin | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Months | 2 Months | Normal | 40-105 | nmol/L | 2 Months | 6 Months | Normal | 23-98 | nmol/L | 6 Months | 24 Months | Normal | 18-58 | nmol/L | 2 Years | 5 Years | Normal | 18-50 | nmol/L | 5 Years | 10 Years | Normal | 9-40 | nmol/L | 10 Years | 15 Years | Normal | 9-32 | nmol/L | Adults: 10-30 nmol/L |
Special Info
Call Client Services to obtain appropriate sample collection containers. Each set consists of 5 numbered centrifuge tubes in a small plastic bag. Tube #3 contains antioxidants necessary to protect the sample from oxidation. One set of tubes is required per patient.