Tetrahydrobiopterin & Neopterin, CSF

Test Mnemonic


CPT Codes

  • 83789 - QTY (1)


  • Tetrahydrobiopterin
  • Neopterin

Performing Laboratory

Medical Neurogenetics

Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
4.5 mLCerebrospinal fluid (CSF)Set of 5 MNG Collection Tubes FrozenCSF should be collected from the first drop into the containers in the order indicated. Fill each tube to the marked line (0.5 mL in tube 1; 1.0 mL in tubes 2, 3, 4, and 5). Place specimens on ice after collection. If specimen is blood contaminated, the tubes should be centrifuged immediately (prior to freezing) and the clear CSF transferred to new similarly labeled tubes then frozen ASAP at -80 C. Call Client Services at 216-444-5755 or 800-628-6816 to obtain sample collection tubes.


Environmental Condition Description

Days Performed

Tue - Fri

Turnaround Time

15 - 17 days


Name Description
High Performance Liquid Chromatography with Fluorescence Detection (HPLC-FL) 
High Performance Liquid Chromatography with Electrochemical Detection 

Reference Range

Sex Age From Age To Type Range Range Unit
   Years5 YearsNormal7-65nmol/L
 5 Years10 YearsNormal7-40nmol/L
 10 Years15 YearsNormal8-33nmol/L
       Adults: 8-28 nmol/L 
Sex Age From Age To Type Range Range Unit
   Months2 MonthsNormal40-105nmol/L
 2 Months6 MonthsNormal23-98nmol/L
 6 Months24 MonthsNormal18-58nmol/L
 2 Years5 YearsNormal18-50nmol/L
 5 Years10 YearsNormal9-40nmol/L
 10 Years15 YearsNormal9-32nmol/L
       Adults: 10-30 nmol/L 

Special Info

Call Client Services to obtain appropriate sample collection containers. Each set consists of 5 numbered centrifuge tubes in a small plastic bag. Tube #3 contains antioxidants necessary to protect the sample from oxidation. One set of tubes is required per patient.