Th/To Antibody
Test Mnemonic
THTO
CPT Codes
- 83516 - QTY (1)
LOINC ®
81742-9
Includes
- Anti-Th/To Ab (RDL)
Performing Laboratory
LabCorp
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Refrigerated | Remove serum from cells ASAP or within 1 hour of collection and transfer into a standard aliquot tube. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Refrigerated | Remove serum from cells ASAP or within 1 hour of collection and transfer into a standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.3 mL | This volume does not allow for repeat testing. |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | 14 days |
| Frozen | 60 days (stable for only one freeze/thaw cycle) |
| Ambient | 7 days |
Days Performed
Varies
Turnaround Time
15 - 22 days
Methodology
| Name | Description |
|---|---|
| Radioimmunoprecipitation Assay (RIPA) |
Reference Range
Special Info
Grossly hemolyzed, contaminated, lipemic or icteric specimens will be rejected.
Clinical Info
The Th/To antibodies are present in 10-19% of patients with limited SSc, in 11% of patients with diffuse cutaneous SSc, and in 3% of patients with primary Raynaud's disease. Anti-Th/To antibody has been shown to be highly specific for patients with SSc.