Trazodone
Test Mnemonic
DESYRL
CPT Codes
- 80338 - QTY (1)
- G0480 - QTY (1)
LOINC ®
4064-2
Aliases
- Desyrel
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Refrigerated | Do not use serum separator tubes. Separate serum from cells within 2 hours of collection. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | EDTA (Lavender) | Refrigerated | Separate plasma from cells within 2 hours of collection. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 12 hours |
| Refrigerated | After separation from cells: 1 week |
| Frozen | After separation from cells: 1 week |
Days Performed
Mon, Thu
Turnaround Time
2 - 6 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
Reference Range
| Trazodone | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | Therapeutic: 0.5 - 2.5 | ug/mL | Years | 99 Years | Normal | Toxic: > 4.0 | ug/mL |
Special Info
Collect specimen prior to next dose - at steady state concentration.
Clinical Info
For therapeutic drug monitoring of antidepressant therapy. Peak plasma levels occur approximately 1 hour after dosing when Trazodone is taken on an empty stomach or 2 hours after dosing when taken with food. Elimination of Trazodone is biphasic, consisting of an initial phase (half-life 3 - 6 hours) followed by a slower phase (half-life 5 - 9 hours).