Trazodone




Test Mnemonic

DESYRL

CPT Codes

  • 80338 / G0480 - QTY (1)

LOINC ®

4064-2

Aliases

  • Desyrel

Includes

  • Trazodone Serum/Plasma

Performing Laboratory

ARUP


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumNo additive (Red) RefrigeratedDo not use serum separator tubes. Separate serum from cells within 2 hours of collection.

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLPlasmaEDTA (Lavender) RefrigeratedSeparate plasma from cells within 2 hours of collection.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.5 mL     

Stability

Environmental Condition Description
AmbientAfter separation from cells: 24 hours
RefrigeratedAfter separation from cells: 2 weeks
FrozenAfter separation from cells: 4 months

Days Performed

Wed

Turnaround Time

2 - 9 days

Methodology

Name Description
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) 

Reference Range

Trazodone
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormalTherapeutic: 800 - 1600ng/mL
   Years99 YearsNormalToxic: Not well establishedug/mL

Special Info

Do not use gel separator tubes. Collect specimen prior to next dose (trough) - at steady state concentration. This test is New York DOH approved.

Clinical Info

Trazodone is a selective serotonin reuptake inhibitor antidepressant drug indicated for the treatment of major depressive disorder. The pharmacokinetics of trazodone is influenced by drug-drug interactions that induce or inhibit CYP3A4 metabolism. Adverse effects may include sedation, fatigue, headache, blurred vision, nausea and cardiac arrhythmia. The risk of serotonin syndrome is increased with concomitant use of other serotonergic drugs. Concomitant use of trazodone with anticoagulants and nonsteroidal anti-inflammatory drugs may increase the risk of bleeding.

Clinical Reference

n/a