von Willebrand Disease Type 2N Binding




Test Mnemonic

VWD2N

CPT Codes

  • 85246 - QTY (1)
  • 85240 - QTY (1)

Aliases

  • FVIII-VWF Binding

Performing Laboratory

Versiti Diagnostic Labs


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.5 mLPlasmaSodium citrate (Lt. Blue) FrozenSeparate plasma from cells ASAP or within 4 hours of collection and freeze.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.3 mL     

Stability

Environmental Condition Description
Ambient4 hours
RefrigeratedUnacceptable
Frozen2 weeks

Days Performed

1 day per week

Turnaround Time

8 - 12 days

Methodology

Name Description
Enzyme-Linked Immunosorbent Assay (ELISA) 

Reference Range

von Willebrand Disease Type 2N Binding
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormal>= 89%

Special Info

do not use glass tubes or pipets, since glass activates the hemostatic mechanism.

Clinical Info

For selection of proper therapy, it is important to distinguish between 2N VWD and hemophilic disorders. Patients with 2N VWD have a very short correction of Factor VIII Coagulant (FVIII:C) levels in response to Desamino-D-Arginine Vasopressin (DDAVP) or purified FVIII replacement therapy. Optimal therapy of patients with type 2N VWD requires replacement with VWF containing concentrates.

Clinical Limitation

n/a

Clinical Reference

n/a