von Willebrand Disease Type 2N Binding
Test Mnemonic
VWD2N
CPT Codes
- 85246 - QTY (1)
- 85240 - QTY (1)
Aliases
- FVIII-VWF Binding
Performing Laboratory
Versiti Diagnostic Labs
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL | Plasma | Sodium citrate (Lt. Blue) | Frozen | Separate plasma from cells ASAP or within 4 hours of collection and freeze. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.3 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 4 hours |
| Refrigerated | Unacceptable |
| Frozen | 2 weeks |
Days Performed
1 day per week
Turnaround Time
8 - 12 days
Methodology
| Name | Description |
|---|---|
| Enzyme-Linked Immunosorbent Assay (ELISA) |
Reference Range
| von Willebrand Disease Type 2N Binding | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | >= 89 | % |
Special Info
do not use glass tubes or pipets, since glass activates the hemostatic mechanism.
Clinical Info
For selection of proper therapy, it is important to distinguish between 2N VWD and hemophilic disorders. Patients with 2N VWD have a very short correction of Factor VIII Coagulant (FVIII:C) levels in response to Desamino-D-Arginine Vasopressin (DDAVP) or purified FVIII replacement therapy. Optimal therapy of patients with type 2N VWD requires replacement with VWF containing concentrates.