von Willebrand Diagnostic Interpretive Panel (Limited)

von Willebrand Diagnostic Interpretive Panel (Limited) Print

Test Mnemonic

VWFPR

CPT Codes

85730 - QTY (1)
85240 - QTY (1)
85245 - QTY (1)
85246 - QTY (1)
85610 - QTY (1)
85247 - QTY (1)
83520 - QTY (1)
85390 - QTY (1)

Includes

Prothrombin Time (PT)
APTT
Collagen Binding Assay(CBA)
Factor VIII assay (FVIII)
von Willebrand Factor Antigen (VWF)
CBA/VWF Ratio
FVIII/VWF Ratio
von Willebrand Multimer
VWF:GpIbM Activity
GpIbM/VWF Ratio

Performing Laboratory

Cleveland Clinic Laboratories

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
6 mL	Plasma	Sodium citrate (Lt. Blue)		Centrifuge, aliquot and freeze ASAP.	Centrifuge samples; Aliquot plasma into a separate tube and label with Epic Beaker labels. Specimens should be frozen (-20C or colder).

Minimum Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
3 mL

Stability

Environmental Condition	Description
Ambient	Unacceptable
Refrigerated	Unacceptable
Frozen	-20° C stable for 2 weeks or -70° C stable for 6 months

Days Performed

Mon - Fri

Turnaround Time

10 days

Methodology

Name	Description
Aggregation
Clotting Assay
Enzyme-Linked Immunosorbent Assay (ELISA)
Latex Immunoassay (LIA)

Reference Range

Activated PTT
Sex	Age From	Age To	Type	Range	Range Unit
	Days	1 Days	Normal	27.1 - 43.7	sec
	2 Days	5 Days	Normal	22.0 - 48.0	sec
	6 Days	30 Days	Normal	22.1 - 44.3	sec
	1 Months	3 Months	Normal	20.8 - 40.2	sec
	4 Months	11 Months	Normal	24.3 - 34.4	sec
	1 Years	99 Years	Normal	23.0 - 32.4	sec
	Years	99 Years	Urgent	> 100.0	sec
	Years	99 Years	Critical	EXTREMELY ABNORMAL RESULT. No clot detected at 320 seconds. Refer to anticoagulation nomogram for further actions.
CBA/VWF Ratio
Sex	Age From	Age To	Type	Range	Range Unit
			Normal	>0.6	.
Factor VIII/VWF Ratio
Sex	Age From	Age To	Type	Range	Range Unit
			Normal	>0.5	.
Factor VIII:C Assay
Sex	Age From	Age To	Type	Range	Range Unit
~	Days	2 Days	Urgent	<=4	%
~	2 Days	6 Days	Urgent	<=4	%
~	30 Days	4 Months	Urgent	<=4	%
~	6 Days	30 Days	Urgent	<=4	%
~	1 Years	6 Years	Urgent	<=4	%
~	11 Years	17 Years	Urgent	<=4	%
~	17 Years	999 Years	Urgent	<=4	%
~	6 Years	11 Years	Urgent	<=4	%
~	4 Months	1 Years	Urgent	<=4	%
GpIbM/VWF Ratio
Sex	Age From	Age To	Type	Range	Range Unit
			Normal	>0.5	.
INR
Sex	Age From	Age To	Type	Range	Range Unit
~	Days	2 Days	Urgent	>=5.1
~	2 Days	6 Days	Urgent	>=5.1
~	6 Days	1 Months	Urgent	>=5.1
~	1 Months	4 Months	Urgent	>=5.1
~	4 Months	1 Years	Urgent	>=5.1
~	1 Years	99 Years	Urgent	>=5.1
	Days	99 Years	Urgent	EXTREMELY ABNORMAL RESULT. No clot detected at 320 seconds. INR unable to be calculated. This could be due to an extreme hemostasis abnormality or a contaminated or clotted specimen. Suggest redraw.
von Willebrand Diagnostic Interpretive Panel
Sex	Age From	Age To	Type	Range	Range Unit
				Refer to reference ranges of individual test components. Reference ranges for calculated ratios:
VWF:GpIbM Activity
Sex	Age From	Age To	Type	Range	Range Unit
			Normal	44-156	%

Special Info

Sample must be accompanied by the completed Clinical History Form for Hemostasis and Thrombosis Evaluation. If test results in panel are abnormal, additional testing may be ordered and billed. These tests include FIX (85250), FXI (85270), FXII (85280), FXIII Antigen (85290), Bethesda Inhibitor (85335), FVIII Chromogenic (85240), DRVVT (85613), Staclot (85730, 85732), PTT MIX (85730), and PNP (85597).

Clinical Info

Evaluation of bleeding disorders caused by abnormalities of von Willebrand factor, especially those accompanied by prolonged PTT and bleeding time. Differentiation of Hemophilia A (Factor VIII deficiency) from von Willebrand disease.

Patient Info Sheet

Clinical History Form for Hemostasis and Thrombosis Evaluation

Reflex Tests

The following additional test(s) may be ordered depending on results: