Elevated PT and PTT Mixing Panel | Cleveland Clinic Laboratories

Elevated PT and PTT Mixing Panel Print

Test Mnemonic

PTPTTE

CPT Codes

85390 - QTY ()
85520 - QTY (1)
85610 - QTY (1)
85611 - QTY (1)
85670 - QTY (1)
85730 - QTY (1)
85732 - QTY (2)

Aliases

Elevated PT / PTT Panel

Includes

PT Screen
PT 1:1 Mix
APTT Screen
Immediate PTT 1:1 Mix
Thrombin Time
Heparin Assay

Performing Laboratory

Cleveland Clinic Laboratories

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
6 mL	Plasma	Sodium citrate (Lt. Blue)		Centrifuge, aliquot and freeze ASAP.	Collection tubes must be filled to total fill volume. Inadequately filled tubes will be rejected. Non-testing sites: Centrifuge samples; Aliquot plasma into a separate tube and label with Epic Beaker labels. Specimens should be frozen (-20C or colder).

Minimum Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
2 mL					Minimum is 2 mL of plasma. NOTE: If only the minimum volume is received, some reflex testing may not be able to be performed.

Stability

Environmental Condition	Description
Ambient	Main Campus: ACCEPTABLE for Whole Blood. (Must be delivered ambient to testing lab less than 4 hours post collection.) Non-Testing Sites: UNACCEPTABLE
Frozen	For Non-Testing Sites: Frozen Plasma is ACCEPTABLE (Centrifuge samples, then aliquot plasma into a separate tube and label with Epic Beaker labels. Specimens should be frozen (-20 degree C or colder) and they are stable for 2 weeks. (6 months at -70 degree C).
Refrigerated	Unacceptable

Days Performed

Mon - Fri

Turnaround Time

1 - 3 days

Methodology

Name	Description
Refer to individual components

Reference Range

APTT Screen
Sex	Age From	Age To	Type	Range	Range Unit
	Days	1 Days	Normal	28.2-47.4	sec
	2 Days	5 Days	Normal	22.9-52.0	sec
	6 Days	30 Days	Normal	23.1-48.0	sec
	1 Months	3 Months	Normal	21.7-43.5	sec
	4 Months	11 Months	Normal	25.3-37.3	sec
	1 Years	5 Years	Normal	21.3-31.6	sec
	6 Years	10 Years	Normal	23.1-31.6	sec
	11 Years	16 Years	Normal	23.1-32.5	sec
	17 Years	99 Years	Normal	24.0-35.1	sec
Immediate PTT 1:1 Mix
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	< 33.2	sec
PT 1:1 Mix
Sex	Age From	Age To	Type	Range	Range Unit
	Days	14 Days	Normal	12.6-16.4	sec
	15 Days	30 Days	Normal	12.0-16.0	sec
	1 Months	5 Months	Normal	11.7-15.7	sec
	6 Months	11 Months	Normal	11.8-14.9	sec
	12 Months	5 Years	Normal	12.1-14.5	sec
	6 Years	10 Years	Normal	11.7-15.1	sec
	11 Years	16 Years	Normal	12.1-15.7	sec
	17 Years	99 Years	Normal	11.6-14.4	sec
PT Screen
Sex	Age From	Age To	Type	Range	Range Unit
	Days	14 Days	Normal	12.6-16.4	sec
	15 Days	30 Days	Normal	12.0-16.0	sec
	1 Months	5 Months	Normal	11.7-15.7	sec
	6 Months	11 Months	Normal	11.8-14.9	sec
	12 Months	5 Years	Normal	12.1-14.5	sec
	6 Years	10 Years	Normal	11.7-15.1	sec
	11 Years	16 Years	Normal	12.1-15.7	sec
	17 Years	99 Years	Normal	11.6-14.4	sec
Thrombin Time
Sex	Age From	Age To	Type	Range	Range Unit
	Days	1 Days	Normal	< 17.3	sec
	2 Days	5 Days	Normal	< 17.9	sec
	6 Days	30 Days	Normal	< 17.9	sec
	1 Months	3 Months	Normal	< 18.2	sec
	4 Months	11 Months	Normal	< 19.1	sec
	1 Years	999 Years	Normal	< 18.6	sec

Special Info

Indicate clearly if patient is on heparin, coumadin, direct thrombin inhibitor or thrombolytic therapy.

Clinical Info

Note: It is recommended that the abnormal PT and APTT be confirmed before ordering this panel. This panel is recommended for the evaluation of coagulation disorders in patients with a prolonged PT and/or a prolonged APTT, whether or not there is a bleeding diathesis. Disorders that may be investigated include common pathway coagulation factor deficiencies (fibrinogen, factors II, V, X), coagulation factor inhibitors, non-specific inhibitors, vitamin K deficiency, hepatic coagulopathy, disseminated intravascular coagulation (DIC), lupus anticoagulants, hypofibrinogenemia, dysfibrinogenemia, or anticoagulant drug effects.

Reflex Tests

The following additional test(s) may be ordered depending on results: