Pathology Insights Video Series

Tumors of the Lung

Presented by Sanjay Mukhopadhyay, MD

In this video, an expert pulmonary pathologist and director of Cleveland Clinic’s Pulmonary Pathology service briefly covers all lung tumor types – including all the subtypes of lung cancer – listed in the new (2021) World Health Organization classification. Dr. Mukhopadhyay then describes the primary pathologic features of these tumors with high-quality pathology images provided in most cases.

This video should be helpful for patients, surgeons, pulmonologists, oncologists, pathologists, residents, and medical students.

Pathology Insights Video Series

Update on Small Round Cell Tumors with Scott Kilpatrick, MD

Presented by Scott Kilpatrick, MD

In this video, Scott Kilpatrick, MD, Director of Orthopedic Pathology at Cleveland Clinic, provides historical context and WHO updates on the evolving classification of undifferentiated round cell sarcomas, including Ewing sarcoma and the so-called Ewing family of sarcomas.

Pathology Insights Video Series

Mammary Myofibroblastoma: A Practical Approach to Pathologic Diagnosis on Core Needle Biopsy

Presented by Miglena Komforti, DO

Myofibroblastoma is an uncommon benign neoplasm of the breast.

Dr. Miglena Komforti, a staff member of Cleveland Clinic’s Breast Pathology Section, discusses the histopathologic findings, ancillary immunohistochemical stains, molecular alterations, and clinical significance of mammary myofibroblastoma.

Pathology Insights Video Series

Diagnosis of Oncocytic Salivary Gland Tumors

Presented by Mobeen Rahman, MD

The diagnosis of oncocytic salivary gland tumors can be challenging, especially on core needle biopsies.

Dr. Mobeen Rahman, staff Head & Neck pathologist, discusses an interesting case that explores this issue.

Pathology Insights Video Series

NUT Carcinoma

Presented by Sanjay Mukhopadhyay, MD

In this video, Sanjay Mukhopadhyay, MD, Director of Pulmonary Pathology at Cleveland Clinic, highlights a rare, aggressive, malignant tumor and draws attention to a distinctive immunohistochemical profile that can serve as a tip-off to the correct diagnosis.

Pathology Insights Video Series

Diagnosis of CD30+ T-cell Lymphoproliferative Disorders

Presented by Genevieve Crane, MD, PhD

The diagnosis of CD30+ T-cell lymphoproliferative disorders, including ALK+ and ALK-negative forms of anaplastic large cell lymphoma, can present challenges. These entities show overlapping morphologic and immunohistochemical features but can vary widely in terms of clinical aggression.

Dr. Genevieve Crane, Staff Hematopathologist at Cleveland Clinic, discusses clinical presentation, morphologic features, and emerging prognostic markers that may aid in diagnosis and clinical management.

Pathology Insights Video Series

Two Diagnoses in One Bone Marrow

Presented by Megan Nakashima, MD

Analysis of a bone marrow requires both careful morphologic examination as well as appropriate ancillary studies.

Dr. Megan Nakashima, Staff Hematopathologist at Cleveland Clinic, discusses a complicated bone marrow case involving a patient with thrombocytopenia, monocytosis, and diarrhea. After requiring the incorporation of molecular and immunophenotypic information, two diagnoses are reached.

In addition to this case, Dr. Nakashima reviews relevant changes in the WHO 2016 classification of myeloid and associated neoplasms.

Pathology Insights Video Series

Diagnosing Microinvasive Breast Cancer in a Background of Intraductal Carcinoma

Presented by Miglena Komforti, DO

In the breast, the pathologic diagnosis of a small focus of invasion can be quite challenging.

Dr. Miglena Komforti discusses the histopathologic findings, ancillary immunohistochemical stains, and clinical significance of microinvasive cancer of the breast.

Pathology Insights Video Series

Diagnosis of Metastatic Renal Cancer

Presented by Sean Williamson, MD

Pathologic diagnosis can be challenging in the setting of poorly-differentiated and metastatic renal cancer.

Dr. Sean Williamson, Director of Genitourinary Pathology at Cleveland Clinic, discusses immunohistochemical and molecular testing used to help confirm the diagnosis.

Pathology Insights Video Series

Pathology of Vaping-Associated Lung Injury

Presented by Sanjay Mukhopadhyay, MD

Sanjay Mukhopadhyay, MD, discusses the findings of a study on the lung pathology of vaping.

Featured in an article co-authored by Dr. Mukhopadhyay and published in the American Journal of Clinical Pathology, the study focuses on the results of microscopic examination of biopsied lung tissue from individuals who developed severe lung illness associated with vaping.

This is one of the first case series in the world to examine lung biopsies from patients with vaping-associated lung illness and is the first-ever study on vaping published in a pathology journal. These findings have important public health implications and are detailed in the video.