March 2025: Test Changes to Oxidized Low-Density-Lipoprotein & Lipoprotein-associated Phospholipase A2 Activity

Special Communication

Test Changes – Oxidized Low-Density-Lipoprotein (OXLDL) & Lipoprotein-associated Phospholipase A2 Activity (PLAA2)

Effective March 18, 2025.

Starting March 18, 2025, Oxidized Low-Density-Lipoprotein (OXLDL) & Lipoprotein-associated Phospholipase A2 Activity (PLAA2) will be sent to a different performing reference laboratory (LabCorp).

Refer to the table below for an outline of testing changes.

Please contact Client Services with any questions or for assistance.

Test Change Overview

Lipoprotein-associated Phospholipase A2 Activity (Lp-PLA2 Activity) (PLAA2)

New Test

Old Test

Performing Laboratory

LabCorp

Cleveland HeartLab

Methodology

Spectrophotometric/Enzymatic assay

Enzymatic assay

Specimen Collection

Serum, 0.5 mL

Gold Serum Separation Tube (SST)

Serum

Minimum Volume

0.2 mL

0.5 mL

Transport Temperature

Refrigerated

Refrigerated

Reference Interval

<225 nmol/min/mL

≤123 nmol/min/mL

Please note the change in units and reference interval.

Turnaround Time

3-5 days

4-5 days

Oxidized Low-Density-Lipoprotein (OXLDL)

New Test

Old Test

Performing Laboratory

LabCorp

Cleveland HeartLab

Methodology

Enzyme-Linked Immunosorbent Assay (ELISA)

Enzyme-Linked Immunosorbent Assay (ELISA)

Specimen Collection

Plasma, 0.5 mL

Lavender K2EDTA Tube

Plasma

Lavender K2EDTA Tube

Minimum Volume

0.2 mL

0.2 mL

Transport Temperature

Critical frozen

Refrigerated

Reference Interval

10-170 ng/mL

<60 U/L

Please note the change in units and reference interval.

Turnaround Time

4-6 days

2-6 days