Biotinidase Serum
Test Mnemonic
BIOTIN
CPT Codes
- 82261 - QTY (1)
LOINC ®
1982-8
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Frozen |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | Sodium or Lithium heparin (Green) | Centrifuge, aliquot and freeze ASAP. | Centrifuge, remove plasma from cells and freeze plasma ASAP. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Unacceptable |
| Refrigerated | 24 hours |
| Frozen | 2 weeks |
Days Performed
Varies
Turnaround Time
14 days
Methodology
| Name | Description |
|---|---|
| Colorimetry |
Reference Range
| Biotinidase Serum | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | 4.4 - 12 | U/L |
Special Info
Centrifuge, aliquot and freeze ASAP.
Clinical Info
Evaluation of individuals with: 1) unexplained seizures; 2) unexplained ataxia; 3) unexplained sensorineural hearing loss, especially if accompanied by neurological abnormalities and/or dermatitis; 4) unexplained dermatitis accompanied by epilepsy, ataxia, mental retardation and/or hearing loss. Partial deficiencies and carriers may occur at the low end of the reference range; restesting of the patient is suggested if the reported enzyme activity is < 4.5 U/L.