Biotinidase Serum




Test Mnemonic

BIOTIN

CPT Codes

  • 82261 - QTY (1)

LOINC ®

1982-8

Performing Laboratory

Cleveland Clinic Laboratories


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumSST (Gold) Frozen 

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLPlasmaSodium or Lithium heparin (Green) Centrifuge, aliquot and freeze ASAP.Centrifuge, remove plasma from cells and freeze plasma ASAP.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.5 mL     

Stability

Environmental Condition Description
AmbientUnacceptable
Refrigerated24 hours
Frozen2 weeks

Days Performed

Varies

Turnaround Time

14 days

Methodology

Name Description
Colorimetry 

Reference Range

Biotinidase Serum
Sex Age From Age To Type Range Range Unit
   Years99 YearsNormal4.4 - 12U/L

Special Info

Centrifuge, aliquot and freeze ASAP.

Clinical Info

Evaluation of individuals with: 1) unexplained seizures; 2) unexplained ataxia; 3) unexplained sensorineural hearing loss, especially if accompanied by neurological abnormalities and/or dermatitis; 4) unexplained dermatitis accompanied by epilepsy, ataxia, mental retardation and/or hearing loss. Partial deficiencies and carriers may occur at the low end of the reference range; restesting of the patient is suggested if the reported enzyme activity is < 4.5 U/L.