Creutzfeldt-Jakob Disease
Test Mnemonic
CJD
CPT Codes
- 84182 - QTY (1)
- 86317 - QTY (1)
- 0035U - QTY (1)
Aliases
- 14 - 3 - 3 Protein
- CJD
- Mad Cow Disease
- Prion Disease
Includes
- 14-3-3 Protein
- Tau Protein
- PrPSC (RT-QuIC)
Performing Laboratory
National Prion Disease Center
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 5 mL | Cerebrospinal fluid (CSF) | Clean container | Frozen | Discard first 2 mL of CSF from tap before starting collection. Avoid a bloody tap. | |
| 100 mL | Urine, random | Clean container | Frozen | Immediately place specimen on ice. A urine sample is requested, but not required, for research purposes only. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | CSF | ||||
| 5 mL | Urine |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 48 hours |
| Frozen | Indefinitely |
| Refrigerated | 2 weeks |
Days Performed
Varies
Turnaround Time
8 - 11 days
Methodology
| Name | Description |
|---|---|
| Enzyme-Linked Immunosorbent Assay (ELISA) | |
| Western Blot (WB) |
Reference Range
Special Info
A completed 'Test Request Form' MUST accompany each sample. CSF should be obtained by lumbar puncture. The first 2 mL of CSF that flows from the tap should be discarded. Avoid a bloody tap because RT-QuIC and 14-3-3 protein tests cannot be performed reliably when there is a significant presence of blood in the CSF specimen.