CV2 Antibody, IgG by CBA-IFA With Reflex to Titer, Serum
Test Mnemonic
CV2
CPT Codes
- 86255 - QTY (1)
Aliases
- CRMP-5
- CV2 Autoantibody Test
Includes
- CV2 Ab IgG CBA-IFA Screen, Serum
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Refrigerated | Separate serum from cells and transfer to standard aliquot tube. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Refrigerated | Separate serum from cells and transfer to standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.25 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | 2 weeks |
| Ambient | 48 hours |
| Frozen | 1 month |
Days Performed
Thu
Turnaround Time
2 - 9 days
Methodology
| Name | Description |
|---|---|
| Semi-Quantitative Cell-Based Indirect Fluorescent Antibody |
Reference Range
| CV2 Ab IgG CBA-IFA Screen, Serum | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Reference Interval: Less than 1:100 |
Special Info
Reflex Algorithm: If CV2 Antibody IgG Screen by IFA is positive, then CV2 Antibody IgG Titer by IFA is performed at an additional cost. Hemolyzed, contaminated, or severely lipemic specimens will be rejected. This test is New York state approved.
Clinical Info
Consider ordering for individuals with paraneoplastic encephalomyelitis, chorea, cerebellar degeneration, optic neuritis, and peripheral neuropathy. May aid in diagnosis of occult or recurrent tumor. CV2 antibodies aid in discriminating between chronic paraneoplastic neurological disorder (PND) and other inflammatory disorders of the nervous system. Anti-CV2 is associated with small-cell lung cancer and thymoma. A negative test result does not rule out a diagnosis of autoimmune neurologic disease. Results should be interpreted in correlation with the patient's clinical history and other laboratory findings.