FISH for ALK (2p23) FFPET NSCLC
Test Mnemonic
FSHLNG
CPT Codes
- 88377 - QTY (1)
Aliases
- Non-small cell lung carcinoma
- FISH for ALK Tissue
Includes
- LSI 2p23.2-p23.1
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 slides | Slide (s), unstained | Clean container | Ambient | One formalin-fixed, paraffin embedded block containing representative tissue OR unstained 4 μm tissue sections on electrostatically charged slides containing representative tumor. Tissue must be fixed in formalin NOT B5 or PREFER fixative |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | FFPE tissue blocks and slides from FFPE specimens are stable at ambient temperatures |
Days Performed
5 days per week
Turnaround Time
5 - 7 days
Methodology
| Name | Description |
|---|---|
| Fluorescent In-Situ Hybridization (FISH) |
Clinical Info
Interphase FISH analysis utilizing a dual color, break-apart probe for the ALK gene at 2p23.2. Rearrangements of the ALK gene may be observed in individuals with late-stage, non-small lung cell cancer who may benefit from specific drug treatment. The translocation partner gene cannot be identified in this assay. If no cells are available for analysis, no analysis charges will be incurred.