FISH FOR BIRC3/MALT1 TRANSLOCATION
Test Mnemonic
T1118
CPT Codes
- 88377 - QTY (1)
Aliases
- FISH for t(11;18)
Includes
- LSI 11q22.3
- LSI 18q21.3
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 slides | Paraffin block, formalin fixed | Slides, unstained | Ambient | One formalin-fixed, paraffin embedded block containing representative tissue OR unstained 4 μm tissue sections on electrostatically charged slides containing representative tumor. Tissue must be fixed in formalin NOT B5 or PREFER fixative |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | FFPE blocks and slides to be transported at ambient temperatures. |
Days Performed
5 days per week
Turnaround Time
3 - 5 days
Methodology
| Name | Description |
|---|---|
| Fluorescent In-Situ Hybridization (FISH) |
Clinical Info
Interphase FISH analysis utilizing a dual color, dual fusion probe set specific to the BIRC3 gene at 11q22.3 and the MALT1 gene at 18q21.3. This translocation may be observed in marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. If no cells are available for analysis, no analysis charges will be incurred.