FISH for CCND1 (Tissue)

Test Mnemonic


CPT Codes

  • 88377 - QTY (1)


  • CCND1 Break Apart by FISH
  • FISH for 11q13 Translocations


  • FISH for t(11;14)(q13;q32)

Performing Laboratory

Cleveland Clinic Laboratories

Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2 slidesTissue, formalin fixedClean containerN/AAmbientOne formalin-fixed, paraffin embedded block containing representative tissue OR unstained 4 μm tissue sections on electrostatically charged slides containing representative tumor. Tissue must be fixed in formalin NOT B5 or PREFER fixative


Environmental Condition Description
AmbientFFPE tissue block or unstained slides from FFPE tissue are stable in ambient environment.

Days Performed

5 days per week

Turnaround Time

3 - 5 days


Name Description
Fluorescent In-Situ Hybridization (FISH) 

Reference Range

FISH for CCND1 (Blood or Bone Marrow)
Sex Age From Age To Type Range Range Unit
       Negative for CCND1 Rearrangement 

Special Info


Clinical Info

Interphase FISH analysis utilizing a dual color, break-apart probe for the CCND1 gene at 11q13.3. Rearrangements of the CCND1 gene are observed in mantle cell lymphoma, a subset of plasma cell myeloma, and other B-cell non-Hodgkin lymphomas. The translocation partner gene cannot be identified in this assay. If no cells are available for analysis, no analysis charges will be incurred.