FISH for TFE3 and TFEB Panel
Test Mnemonic
TFEFSH
CPT Codes
- 88377 - QTY (2)
Includes
- LSI 6p21.1
- LSI Xp11.23
Performing Laboratory
n/a
Specimen Requirements
Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
---|---|---|---|---|---|
4 slides | Paraffin block, formalin fixed | Slides | Ambient | Pre and Post H&E with four unstained slides with defined marked areas for analysis. |
Minimum Specimen Requirements
Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
---|---|---|---|---|---|
4 slides | Pre and Post H&E with four unstained slides with defined marked areas for analysis. |
Stability
Environmental Condition | Description |
---|---|
Ambient | FFPE slides or formalin-fixed blocks at room temperature |
Days Performed
5 days per week
Turnaround Time
5 - 7 days
Methodology
Name | Description |
---|---|
Fluorescent In-Situ Hybridization (FISH) |
Clinical Info
Interphase FISH analysis utilizing dual color, break-apart probe sets for the TFEB gene at 6p21.1 and the TFE3 gene at Xp11.23. This is useful in the identification and accurate classification of renal cell carcinomas. The translocation partner genes cannot be identified in this assay. The TFEB probe set also allows for the identification of TFEB amplification, which has been associated with a more aggressive class of renal carcinomas. If no cells are available for analysis, no analysis charges will be incurred.