FISH for TFE3 and TFEB Panel




Test Mnemonic

TFEFSH

CPT Codes

  • 88377 - QTY (2)

Includes

  • LSI 6p21.1
  • LSI Xp11.23

Performing Laboratory

n/a


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
4 slidesParaffin block, formalin fixedSlidesAmbient Pre and Post H&E with four unstained slides with defined marked areas for analysis.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
4 slides    Pre and Post H&E with four unstained slides with defined marked areas for analysis.

Stability

Environmental Condition Description
AmbientFFPE slides or formalin-fixed blocks at room temperature

Days Performed

5 days per week

Turnaround Time

5 - 7 days

Methodology

Name Description
Fluorescent In-Situ Hybridization (FISH) 

Clinical Info

Interphase FISH analysis utilizing dual color, break-apart probe sets for the TFEB gene at 6p21.1 and the TFE3 gene at Xp11.23. This is useful in the identification and accurate classification of renal cell carcinomas. The translocation partner genes cannot be identified in this assay. The TFEB probe set also allows for the identification of TFEB amplification, which has been associated with a more aggressive class of renal carcinomas. If no cells are available for analysis, no analysis charges will be incurred.