FISH for TFEB
Test Mnemonic
TFEBFH
CPT Codes
- 88377 - QTY (1)
Includes
- LSI 6p21.1
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 slides | Paraffin block, formalin fixed | Slides | Ambient | Pre and Post H&E with two unstained slides with defined marked areas for analysis. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 slides | Pre and Post H&E with two unstained slides with defined marked areas for analysis. |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | FFPE slides at room temperature |
Days Performed
5 days per week
Turnaround Time
5 - 7 days
Methodology
| Name | Description |
|---|---|
| Fluorescent In-Situ Hybridization (FISH) |
Clinical Info
Interphase FISH analysis utilizing a dual color, break-apart probe for the TFEB gene at 6p21.1. This is useful in the identification and accurate classification of renal cell carcinomas. This probe set also allows for the identification of TFEB amplification, which has been associated with a more aggressive class of renal carcinomas. The translocation partner gene cannot be identified in this assay. If no cells are available for analysis, no analysis charges will be incurred.