IgG Synthesis, CSF (Tourtellotte and Index)




Test Mnemonic

TOURT

CPT Codes

  • 82784 - QTY (2)
  • 82042 - QTY (1)
  • 82040 - QTY (1)

Aliases

  • Tourtellote Formula

Includes

  • CSF IgG
  • CSF Albumin
  • Serum IgG
  • Serum Albumin
  • CNS IgG Synthesis
  • CSF IgG Index
  • CSF IgG/Albumin Ratio

Performing Laboratory

Cleveland Clinic Laboratories


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLCerebrospinal fluid (CSF)Clean container RefrigeratedCollect cerebrospinal fluid (CSF) and blood within same 24-hour period.
1 mLSerumSST (Gold) RefrigeratedCollect cerebrospinal fluid (CSF) and blood within same 24-hour period.

Alternate Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
1 mLSerumNo additive (Red)   

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.2 mL    Serum
0.5 mL    CSF

Stability

Environmental Condition Description
Ambient24 hours
Refrigerated7 days
Frozen14 days

Days Performed

Mon - Fri

Turnaround Time

1 - 4 days

Methodology

Name Description
Bromocresol Green 
Immunoradiometric Assay 

Reference Range

Albumin, CSF
Sex Age From Age To Type Range Range Unit
 3 Months47 MonthsNormalless than 45mg/dL
 4 Years99 YearsNormal10 - 30mg/dL
Albumin, Serum
Sex Age From Age To Type Range Range Unit
   Days4 DaysNormal2800 - 4400mg/dL
 5 Days364 DaysNormal3800 - 5400mg/dL
 1 Years14 YearsNormal3800 - 5400mg/dL
 15 Years17 YearsNormal3200 - 4500mg/dL
 18 Years99 YearsNormal3900 - 4900mg/dL
IgG Index, CSF
Sex Age From Age To Type Range Range Unit
       0 - 0.61 
IgG Synthesis, CSF (Tourtellotte)
Sex Age From Age To Type Range Range Unit
       Normal0 - 3.0mg/d
IgG, CSF
Sex Age From Age To Type Range Range Unit
       Normal1.0 - 3.0mg/dL
IgG, Serum
Sex Age From Age To Type Range Range Unit
   Months11 MonthsNormal232 - 1411mg/dL
 1 Years3 YearsNormal453 - 916mg/dL
 4 Years6 YearsNormal504 - 1465mg/dL
 7 Years9 YearsNormal572 - 1474mg/dL
 10 Years11 YearsNormal698 - 1560mg/dL
 12 Years13 YearsNormal759 - 1550mg/dL
 14 Years15 YearsNormal716 - 1711mg/dL
 16 Years19 YearsNormal549 - 1584mg/dL
 20 Years99 YearsNormal700 - 1600mg/dL
IgG,CSF / Albumin,CSF Ratio
Sex Age From Age To Type Range Range Unit
       Normal0.06 - 0.17.

Clinical Info

Determination of intrathecal IgG synthesis as an aid in the evaluation of CNS autoimmune diseases especially multiple sclerosis, and CNS infections such as neurosyphilis and neuroborreliosis, among others.