Itraconazole
Test Mnemonic
ITRAC
CPT Codes
- 80189 - QTY (1)
Aliases
- Sporanox
Includes
- Itraconazole Level
- Hydroxyitraconazole Level
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL | Serum | No additive (Red) | Refrigerated | Do not use serum separator tubes. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.2 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 15 days |
| Refrigerated | After separation from cells: 15 days |
| Frozen | After separation from cells: 60 days |
Days Performed
3 days per week
Turnaround Time
1 - 4 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
Reference Range
| Hydroxyitraconazole | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| No Reference Range is Provided | |||||
| Itraconazole | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.5 - 3.0 | ug/mL |
Special Info
Clinical Info
Ranges are based on trough draw at steady-state concentration. Test performed by LC-MS/MS. Ranges are based off the Itraconazole trough levels alone, not combined with hydroxyitraconazole: Therapeutic: >1.0 µg/mL Prophylaxis: >0.4 µg/mL Toxic: >3.0 µg/mL (Toxic values will not be called.) The therapeutic, prophylactic, and toxic ranges were based on the 2016 Infectious Disease Society (IDSA) Clinical Practice Guidelines for the Management of Aspergillosis and consultation from Cleveland Clinic’s Department of Infectious Disease. Reference ranges and high/low indicator flags are provided as general guidelines only. The treating physician must determine appropriate target levels/dosing based on the specific clinical situation.