Liver Fibrosis, FibroTest-ActiTest
Test Mnemonic
LIVFIB
CPT Codes
- 81596 - QTY (1)
LOINC ®
Not available
Aliases
- FibroTest
- Liver Acti
- Liver Fibrosis
- Necroinflammatory Activity Score
Includes
- Alanine aminotransferase (ALT)
- Alpha 2-Macroglobulin
- Apolipoprotein A1
- Bilirubin, Total
- Gamma-glutamyl Transferase (GGT)
- Haptoglobin
- Fibrosis Score
- Necroinflammat Act Score
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Serum | SST (Gold) | Refrigerated | Centrifuge within 2 hours from collection. Protect serum from light after centrifugation. Overnight fasting is preferred. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Serum | No additive (Red) | Refrigerated | Centrifuge within 2 hours from collection. Transfer serum into a standard or amber aliquot tube. Protect serum from light after centrifugation. Overnight fasting is preferred. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 24 hours |
| Refrigerated | 7 days |
| Frozen | -20 C: Not acceptable; -70 C: 28 days |
Days Performed
Mon - Sat
Turnaround Time
2 - 5 days
Methodology
| Name | Description |
|---|---|
| Spectrophotometry (S) | |
| Colorimetric Enzyme Assay | |
| Immunoturbidometric Assay |
Special Info
Protect from light. Avoid freeze/thaw cycles of specimen. Overnight fasting is preferred. Grossly hemolyzed and grossly lipemic specimens will be rejected. Specimens from patients less than 2 years old are unacceptable. Additionally, specimens QNS for one or more analytes will not be accepted.
Clinical Info
The FibroTest-ActiTest interpretation is a proprietary algorithm owned by BioPredictive. FibroTest and ActiTest permit the non-invasive evaluation of Hepatitis B or C individuals for the presence of liver fibrosis and liver inflammation, respectively. The FibroTest and ActiTest scores are calculated based on patient age, gender and concentrations of serum of y-glutamyl transferase (GGT), total bilirubin (TB), a-2 macroglobulin, haptoglobin, apolipoprotein A1 and alanine aminotransferase (ActiTest). Fibrotest and ActiTest Scores, on a scale of 0.0 to 1.0, are assigned a Metavir scale indicating the level of fibrosis or inflammation present.
Clinical Limitation
Specimens from patients less than 2 years of age are unacceptable.