Metanephrines, Urine Random




Test Mnemonic

UMETRA

CPT Codes

  • 83835 - QTY (1)

Includes

  • Metanephrine
  • Normetanephrine
  • Metanephrine Total

Performing Laboratory

Cleveland Clinic Laboratories


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
10 mLUrine, randomClean container RefrigeratedAdjust urine pH to 3 or less by adding 6M HCl in 1 mL increments if storage/transport will be greater than 24 hours from end of collection.

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
3 mL     

Stability

Environmental Condition Description
Ambient7 days
Refrigerated2 weeks
Frozen1 month

Days Performed

Tue, Fri

Turnaround Time

1 - 9 days

Methodology

Name Description
High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) 

Reference Range

Metanephrine
Sex Age From Age To Type Range Range Unit
       Normal0 - 227ug/g crt
Metanephrine Total
Sex Age From Age To Type Range Range Unit
       Normal100 - 677ug/g crt
Normetanephrine
Sex Age From Age To Type Range Range Unit
       Normal100 - 450ug/g crt

Special Info

Adjust urine pH to 3 or less by adding 6M HCl in 1 mL increments if storage/transport will be greater than 24 hours from end of collection. Specimen stability is currently based on sample with a pH of 3 or less.

Clinical Info

Evaluate catecholamine production; diagnose pheochromocytoma. The total metanephrines is equal to the sum of metanephrine plus normetanephrine. Typically, patients with essential hypertension have total metanephrine results less than 1500 ug/24 hours. Total metanephrine results greater than 1500 ug/24 hours can be seen in life-threatening illness, intense physical exercise, or neuroendocrine tumors.

Clinical Limitation

Urine Metanephrine test performed by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). Results obtained with different methods or kits cannot be used interchangeably.