Myeloid NGS Panel Other




Test Mnemonic

MYNGSO

CPT Codes

  • 81455 - QTY (1)

Aliases

  • CSF3R
  • SF3B1
  • Chronic Myeloid Neoplasm NGS Panel Other

Performing Laboratory

Cleveland Clinic Laboratories


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
TenSlide(s), unstained & unbakedSlides, unstainedAmbientAmbientNeed 10 charged, unbaked, unstained slides or 10 x 7 micron curls (scrolls) plus 1 H&E with best tumor area circled containing at least 10% tumor.

Stability

Environmental Condition Description
AmbientClot section slides and curls are transported and stored at ambient temperature or refrigerated indefinitely.
RefrigeratedClot section slides and curls are transported and stored at ambient temperature or refrigerated indefinitely
FrozenUNACCEPTABLE

Days Performed

Mon - Fri

Turnaround Time

10 days

Methodology

Name Description
Next Generation DNA Sequencing 

Special Info

the following genes are interrogated: ABL1, ASXL1, BCOR, BCORL1, BRAF, CALR, CBL, CDKN2A, CEBPA, CSF3R, CUX1, DDX41, DNMT3A, EED, ETNK1, ETV6, EZH2, FBXW7, FLT3, GATA1, GATA2, GNAS, IDH1, IDH2, IKZF1, JAK2, JAK3, KDM6A, KIT, KMT2A, KRAS, LUC7L2, MPL, MYD88, NF1, NOTCH1, NPM1, NRAS, PAX5, PHF6, PIGA, PPMID, PRPF8, PTEN, PTPN11, RAD2, RIT1, RUNX1, SETBP1, SF3B1, SH2B3, SMC1A, SMC3, SRSF2, STAG2, STAT3, STAT5B, SUZ12, TET2, TP53, U2AF1, WT1, and ZRSR2.

Clinical Info

Molecular evaluation of known or suspected chronic myeloid neoplasms, including but not limited to myeloproliferative neoplasms, myelodysplastic syndromes, and overlap myelodysplastic/myeloproliferative neoplasms. Evaluates for single nucleotide variants, small insertions and deletions within the covered regions of the targeted genes.

Clinical Limitation

This test does not evaluate for fusions. For a combined evaluation including fusions relevant to acute leukemias, the Acute Leukemia NGS panel is recommended.