Myeloid Panel NGS Bone Marrow




Test Mnemonic

MYNGSM

CPT Codes

  • 81455 - QTY (1)

Aliases

  • Chronic Myeloid Neoplasm Panel Bone Marrow
  • CSF3R
  • SF3B1

Performing Laboratory

Cleveland Clinic Laboratories


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
4 mLAspirate, bone marrowEDTA (Lavender)AmbientRefrigerated 

Stability

Environmental Condition Description
AmbientIf specimen is to be stored longer than 24 hours, it should be placed at 2-8 C for up to 7 days.
FrozenUNACCEPTABLE
Refrigerated7 days

Turnaround Time

10 days

Methodology

Name Description
Next Generation DNA Sequencing 

Special Info

The following genes are interrogated: ABL, ASXL1, BCOR, BCORL1, BRAF, CALR, CBL, CDKN2A, CEBPA, CSF3R, CUX1, DDX41, DNMT3A, EED, ETNK1, ETV6, EZH2, FBXW7, FLT3, GATA1, GATA2, GNAS, IDH1, IDH2, IKZF1, JAK2, JAK3, KDM6A, KIT, KMT2A, KRAS, LUC7L2, MPL, MYD88, NF1, NOTCH1, NPM1, NRAS, PAX5, PHF6, PIGA, PPMID, PRPF8, PTEN, PTPN11, RAD2, RIT1, RUNX1, SETBP1, SF3B1, SH2B3, SMC1A, SMC3, SRSF2, STAG2, STAT3, STAT5B, SUZ12, TET2, TP53, U2AF1, WT1, and ZRSR2.

Clinical Info

Molecular evaluation of known or suspected chronic myeloid neoplasms, including but not limited to myeloproliferative neoplasms, myelodysplastic syndromes, and overlap myelodysplastic/myeloproliferative neoplasms. Evaluates for single nucleotide variants, small insertions and deletions within the covered regions of the targeted genes.

Clinical Limitation

This test does not evaluate for fusions. For a combined evaluation including fusions relevant to acute leukemias, the Acute Leukemia NGS panel is recommended.