OSHA Zinc Protoporphyrin
Test Mnemonic
OSHALZ
CPT Codes
- 83655 - QTY (1)
- 84202 - QTY (1)
Aliases
- Industrial Zinc Protoporphyrin
- ZPOSHA
Includes
- Zinc Protoporphyrin, Whole Blood
- Zinc Protoporphyrin to Heme Ratio
- Lead, Whole Blood
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Whole blood | EDTA (Navy Blue) | Refrigerated | THIS TEST REQUIRES TWO SPECIMEN TUBES. Collect 1 ml whole blood in each of 2 EDTA navy tubes. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Whole blood | EDTA (Lavender) | Refrigerated | THIS TEST REQUIRES TWO SPECIMEN TUBES. Collect 1 ml whole blood in each of 2 EDTA navy tubes. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL | 0.5 ml whole blood in each of 2 EDTA tubes. |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 30 hours |
| Refrigerated | 5 weeks |
| Frozen | Unacceptable |
Days Performed
Mon - Fri
Turnaround Time
2 - 5 days
Methodology
| Name | Description |
|---|---|
| ICP/Mass Spectrometry | |
| Quantitative hematofluorometry |
Reference Range
| Lead | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | <3.5 | ug/dL | Years | 99 Years | Urgent | > 44.9 | ug/dL |
| ZPP to heme ratio | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | 0 - 69 | umol ZPP/mol heme | |
| ZPP, whole blood | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | 0 - 40 | ug/dL |
Special Info
Submit Heavy Metals requisition with specimen. Provide all required demographics to meet State Health Department requirements. Lead testing performed in house at Cleveland Clinic Laboratories.
Clinical Info
For occupational exposure to lead, OSHA requires ZPP whole blood concentration to be reported in units of ug/dL. For adults, conversion of ZPP to units of ug/dL assumes a hematocrit of 45%. Elevated ZPP results are seen in early and late iron deficiency, the anemia of chronic disease, chronic lead poisoning, and erythropoietic protoporphyria. Elevated bilirubin or riboflavin and hemolyzed, clotted, or improperly aliquoted specimens may falsely increase the ZPP concentration.